Leukotriene A4 methyl ester
from
Cayman Chemical
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Product
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Leukotriene A4 methyl ester
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Company
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Cayman Chemical
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Price
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Pricing Info
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More Information
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View Company Product Page
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Conjugate/Tag/Label
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Unconjugated
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Molecule Name
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Leukotriene A4 methyl ester
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Original Item Name
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Leukotriene A4 methyl ester
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Target/Molecule Synonym
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LTA4 methyl ester
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Catalog Number
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20010
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Quantity
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.1 mg
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Description
Leukotriene A4 (LTA4) is synthesized in mast cells, eosinophils, and neutrophils from arachidonic acid by 5-lipoxygenase (5-LO), which exhibits both lipoxygenase and LTA4 synthase activities. LTA4 is rapidly metabolized by LTA4 hydrolase or LTC4 synthase to LTB4 or LTC4, respectively. LTA4, from leukocytes, is known to undergo transcellular metabolism in platelets, erythrocytes, and endothelial cells. Further metabolism of LTA4 by 15-LO leads to lipoxin biosynthesis. LTA4 as a free acid is highly unstable. The methyl ester is stable and can be readily hydrolyzed to the free acid as needed.