12-epi Leukotriene B4
from
Cayman Chemical
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Product
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12-epi Leukotriene B4
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Company
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Cayman Chemical
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Price
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Pricing Info
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More Information
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View Company Product Page
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Conjugate/Tag/Label
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Unconjugated
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Molecule Name
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12-epi Leukotriene B4
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Original Item Name
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12-epi Leukotriene B4
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Target/Molecule Synonym
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12-epi LTB4
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Catalog Number
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20135
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Quantity
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.1 mg
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Description
Leukotriene B4 (LTB4) compounds are produced by both enzymatic and non-enzymatic processes. The products of enzymatic origin, via Leukotriene A4 (LTA4) hydrolase, are stereospecifically 12(R). Non-enzymatic hydrolysis products are 50:50 mixtures at C-12, but are almost exclusively trans at C-6. Thus, the non-enzymatic hydrolysis product of LTA4 is 6-trans-12-epi LTB4. 12-epi LTB4 is an isomer which would not be expected to occur in either non-enzymatic hydrolysis products, or in the enzymatic products of LTA4 hydrolase. Compared to LTB4, 12-epi LTB4 has significantly reduced activity for the LTB4 receptor on human neutrophils (IC50 of 7.5 mM), and on guinea pig lung membranes with a (Ki of 4.7 mM). 12-epi LTB4 is an weak agonist at both the recombinant human BLT1 and BLT2 receptors, requiring approximately 10 mM for full activation of the receptor.