Leica M205A -- One Scope For Quality Overview And Detail 3D Images

March 29, 2017

Albert Einstein College of Medicine
Dominick P. Purpura Department of Neuroscience
Graduate student

Overall

Performance

Ease-of-Optimization

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Company:

Leica Microsystems

Product Name:

Leica M205A Stereomicroscope

Catalog Number:

M205A

The Leica M205A stereomicroscope has been used in our lab for taking quality images of the entire mouse brain. Motorized zoom allows for easy optimization and reproduction of settings.

Experimental Design and Results Summary

Application

Bright field and fluorescent microscopy

Starting Material

Dissected mouse brain, fixed or unfixed

Protocol Overview

Place sample under microscope lens and use software to select filters and adjust exposure times.

Tips

Make sure to adjust exposure times for each channel that you select.

Results Summary

Results obtained from this microscope were primarily black and white or color images of the entire mouse brain. Images taken on this microscope have been used to compare mouse brain size and to determine the spread of GFP-expressing virus from the target injection site.

Features Summary

Motorized, fully apochromatic 20.5:1 zoom provides quality overview and detail observation without needing to use a second instrument. Settings can be easily reproduced between experiments.

DOI or PMID #

N/A

Additional Notes

N/A

Image Gallery

Summary

The Good

Quality overview and detail images on a single instrument

The Bad

It takes some time to get used to the software and optimize the settings.

The Bottom Line

Really useful piece of equipment for taking quality, publication-level bright field and fluorescent images of larger-sized samples, such as the mouse brain.

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