Inhibitor Of The Transforming Growth Factor-ß

October 04, 2016

Boston University
Center for Regenerative Medicine
Postdoctoral Associate

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Quality of Results

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Company:

Tocris Bioscience

Product Name:

SB 431542

Catalog Number:

1614

The aim of this project was to inhibit the TGF-beta signaling pathway during the directed differentiation protocol. The product has proven stability & has been used by various labs.

Experimental Design and Results Summary

Application

Directed differentiation protocol

Starting Material

Mouse embryonic stem cells

Protocol Overview

SB431542 at 1ul/ml concentration was added to cells cultured in complete-serum free media.

Tips

Freeze aliquots at -20 degrees Celsius.

Results Summary

Inhibition of TGF-β promoted the anteriorisation of endoderm in the directed differentiation protocol.

Additional Notes

None

Image Gallery

Summary

The Good

Easy to reconstitute, very stable.

The Bad

None

The Bottom Line

A very stable, potent and selective inhibitor of TGF-β.

Product Name: SB 431542Supplier Page

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