SIGMA
Anti HP1 alpha
H2164
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HP1 proteins bind to DNA regions to control gene expression and heterochromatin formation and maintenance. The amount of chromocenters detected by HP1 staining is a clear indication of alterations of some cellular processes, like chromatin regulation during cell division.
Immunofluorescence
MEFs
1/50
1%BSA-TBS
Anti Rb ALEXA 488
Not needed
Confocal
Absence of protein at cytosol. Protein detected in spots in nuclei (chromocenters)
None
Specificity.
Any remarkable.
Chromocenters appear well defined using anti HP1a antibody