SNP Assay, Scoring And Analysis Services

SNP Assay, Scoring And Analysis Services

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CNV Analysis Service

CNV Analysis Service

Creative Biomart

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  • Description:

    Agilent aCGH Technology

    Agilent's oligonucleotide aCGH platform offers genome-wide as well as customized profiling on 60-mer oligo CGH microarrays for human, mouse and rat. Agilent's CGH end-to-end solution consists of flexible microarray formats, optimized and easy-to-use protocol, high resolution microarray scanning and powerful analytics software.

    Features:

    • High-resolution
    • Supports a variety of formats, probes, and species
    • Custom arrays with user-defined content
    • Commercial arrays with standard content
    • Genome-wide studies
    • Focused-content studies

      SNP Arrays

      Both Affymetrix and Illumina offer solutions for CNV analysis using SNP arrays. CD Genomics provides wet lab and data analysis services for each platform.

      Features:

      • Analyze SNP and CNV data across millions of markers
      • Estimate Log R ratio and B-allele frequency for copy number analysis
      • Call genotypes, normalize and cluster data, and generate SNP statistics
      • Export genotype data to various third party applications; access multiple CNV algorithms and CNV analysis tools
      • Generate a chromosomal heat map for examining copy number aberrations across the entire genome for multiple samples

        Your Benefits

        • Free advice on experimental design
        • Peace of mind of using a laboratory with extensive experience of running small, medium and large-scale projects
        • Excellent data quality
        • Lowest costs
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KASP SNP Genotyping Service

KASP SNP Genotyping Service

Creative Biomart

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  • Description: KASP genotyping assays are based on competitive allele-specific PCR and enable biallelic scoring of single nucleotide polymorphisms (SNPs) and insertions and deletions (InDels) at specific loci. Analysis can be carried out in 96-, 384- and 1536-well plate formats. Using KASP genotyping assay, we are able to provide complete genotyping services to our customers. We have a track record of delivering the highest quality data, delivering break-through cost savings across a huge range of project types, and working with hundreds of different species.

    Our Expertise
    • More than 20,000 individual genotyping projects
    • A billion data points generated
    • Experience hundreds of different species
    • Supporting life science researchers in diverse application areas including - Crop and livestock development, Healthcare, Early stage research and diagnostics applications
    Quality Control
    • Quality and quantity control of genomic DNA by agarose gel analysis
    • Negative control in each sample processing batch to exclude DNA contamination
    • Positive control in each sample processing batch to ensure a technically correct laboratory process
    • All quality assurance procedures are electronically documented and available for our customers on demand
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MassARRAY SNP Genotyping Service
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  • Description:

    The Sequenom MassARRAY® System offers MALDI-TOF mass spectrometry for high accuracy and sensitivity, robust chemistry for reproducible results, and advanced data analysis software to meet the needs of any genomic laboratory. This system utilizes a homogenous MassExtend (hME – single base extension) reaction termed iPLEX GOLD, for analysis of SNPs in multiplex format. Following the MassExtend reaction, oligonucleotides are printed onto specialized Spectro CHIPs and analyzed by the Sequenom mass spectrometer. The mass spectrometer provides a high level of sensitivity, capable of detecting allele frequencies as low as 3% on average.

    Service Range

    • Design of customized SNP panels using your content
    • Oligo manufacture and pool balancing
    • Running of iPLEX chemistry
    • Spot and fire of SpectroCHIP using MassARRAY System
    • Analysis of genotypes and delivery of genotype report

      Advantages

      • Very fast assay design: a new assay can be designed within a few hours. In addition, a semi-automated workflow and unmodified oligos provide rapid turnaround times
      • Highly precise and quantitative detection
      • High degree of multiplexing
      • High SNP conversion rates: >95%
      • Assay works well with degraded DNA from formalin-fixed paraffin embedded (FFPE) tissue
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Microsatellite Genotyping Service
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  • Description:

    The PCR reaction is performed with fluorescent dye-labeled primers, then the PCR fragments can be analyzed on a capillary DNA sequencing machine (ABI 3730xl DNA Analyzer), and the data is analyzed using AB GeneMapper software. By taking advantage of multiplexing by fragment size and dye color, and the ability of automated fluorescent genetic analyzer machines to autoload 16 samples at a time from 96-well or even 384-well microtitre plates, high throughput marker analysis experiments can be designed. This service has been applied to a wide variety of species and can accommodate any species for which microsatellite markers are available.

    Applications

    Microsatellite genotyping has been used in thousands of linkage analyses of Mendelian traits to detect co-segregation of a distinct phenotype with a particular microsatellite allele in a family. It has also been used to identify genes in complex diseases.

    Why Choose CD Genomics?

    • Quality: Backed by nearly ten years experience and with a track record of successes in detecting linkage, our contract research is fast and accurate.
    • Pricing: Our high throughputs reduce unit labor and capital costs meaning that we can offer exceptional value for money. Furthermore, savings are made by bulk purchase of reagents.
    • Personal touch: We work with each customer to ensure optimization of experimental design. All data is sent in strictest confidence to you.
    • Commitment to improvement: We are continuously introducing new technologies to reduce costs, shorten timelines and reduce consumables including your DNA.
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Whole-Genome SNP Genotyping Service
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  • Description:

    Affymetrix Whole-Genome SNP Genotyping Service

    Affymetrix was among the first companies in the field to launch human whole-genome SNP genotyping chips. In addition, whole-genome SNP genotyping chips are available for various model organisms including mouse.

    Illumina Whole-Genome SNP Genotyping Service

    Outstanding characteristics of the Illumina's BeadArray technology include 100% quality control of every single array, and high feature-redundancy providing high-confidence results.

    Illumina Custom Genotyping Service

    Based on Illumina Golden Gate Genotyping System and Infinium iSelect HD Custom Genotyping Panels, CD Genomics also offers a custom SNP service which can be tailored to meet specific project requirements.

      Illumina Custom GoldenGate Genotyping

      CD Genomics utilizes the high through-put Illumina iScan System to deliver the GoldenGate Genotyping Assay, a flexible and cost effective SNP assay. These custom GoldenGate panels can be custom designed to meet the researchers' needs, providing greater flexibility with user defined content across a wide range of genomes. CD Genomics can assist and facilitate in the selection of markers based on your region and density requirements.

      Infinium iSelect HD Custom Genotyping Panels

      The Infinium iSelect HD Genotyping BeadChip is extremely flexible, allowing researchers to select practically any SNP in the genome for any species of interest. With iSelects high throughput capabilities, it offers the ability to simultaneously process up to 24-samples and screen between 3,000 and 200,000 custom SNPs. The iSelect BeadChips utilise Infinium chemistry for performing large scale custom genotyping, such as fine mapping.

    Advantages

    • Speed (millions of SNPs are simultaneously determined)
    • The low amount of genomic DNA needed
    • High call rates >99%, and high accuracy

      Service Range

      Our Full Service covers the complete process, from quality control of genomic DNA, to determination of genotypes.

      Quality Control

      • Quality and quantity control of genomic DNA by agarose gel analysis
      • Negative control in each sample processing batch to exclude DNA contamination
      • Positive control in each sample processing batch to ensure a technically correct laboratory process
      • All quality assurance procedures are electronically documented and available for our customers on demand
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Whole-Genome SNP Genotyping Service for Production Animals
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  • Description:

    For a variety of production animals, draft assemblies of the genome are nowadays available, as well as growing information about genetic variations such as single nucleotide polymorphisms (SNPs). This enabled the design of whole-genome SNP chips which are increasingly used to map quantitative trait loci (QTLs) as well as loci associated with economical traits of production animals. CD genomics employs Illumina's unique BeadArray technology providing genotyping services for various production animals. Outstanding characteristics of the BeadArray technology include 100% quality control of every single array, and the high feature-redundancy providing high-confidence results.

    Illumina's Whole-Genome SNP Genotyping Portfolio for Production Animals

    • Bovine SNP50
    • Bovine HD
    • Porcine SNP60
    • Ovine SNP50
    • Equine SNP50
    • Canine SNP20
    • Canine HD

      Service Range

      Our full service covers the complete process, from quality control of genomic DNA, to determination of genotypes.

      Quality Control

      • Quality and quantity control of genomic DNA by agarose gel analysis
      • Negative control in each sample processing batch to exclude DNA contamination
      • Positive control in each sample processing batch to ensure a technically correct laboratory process
      • All quality assurance procedures are electronically documented and available for our customers on demand

        Why Choose CD Genomics' Services?

        • Our service is fast, cost-effective and extremely reliable
        • We offer professional assistance for both planning experiments as well as further data analysis and interpretation
        • We offer further technical support for follow-up studies
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Custom SNP Genotyping Services
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  • Description: CD Genomics offers a one-stop service from SNP discovery to SNP genotyping on a wide range of platforms. A customized platform will be employed according to our client's needs. They offer a scaleable solution from genome wide association studies on tens of thousands of samples to single SNP interrogations of several hundred individuals. Through the participation of the International HapMap project, our staff scientists have accumulated extensive experience and can guarantee the high data quality with fast turnaround rate.
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SNP Discovery & Resequencing Services
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  • Description: CD Genomics provides a one-stop solution for SNP discovery & resequencing, from primer design and synthesis, PCR amplification and purification, to DNA sequencing with automated or manual basecalling. A proven track record of customer satisfaction has been established by their experienced bioinformaticians who have processed more than ten thousand trace files.
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