Antibody microarrays, also referred to as antibody arrays or antibody chips, are specific protein microarrays consisting of a collection of capture antibodies fixed on a solid surface such as glass, plastic or silicon, for the purpose of detecting antigens. These arrays are often used for detecting protein expressions from cell lysates in general research and special biomarkers from serum or urine for diagnostic applications, identifying biomarkers and developing drug compounds. Arrays allow protein expression profiling, screening, and comparison between normal, diseased or treated samples. Arrays are available in one or two slides, one slide is for a control sample, and the other is for a treated sample. Hormone antibodies, cell cycle antibodies and stem cell antibodies are examples of the types of arrays available for high throughput screening. Factors to consider when selecting an antibody array are sample type (e.g. cells, tissue, or serum), detectable change in expression levels, protein labeling, method of detection and type of analysis. A busy lab has the options of sending sample out for analysis or conducting an in-house analysis with a quality, commercially produced antibody microarray.
These arrays can save researchers sample, time, and money.
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