Sequence Analysis (Free Downloads)

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Description: Lasergene Core Suite is a comprehensive DNA and protein sequence analysis software suite comprised of ten applications which include functions ranging from sequence assembly and SNP detection, to automated virtual cloning and primer design, to creating publication-quality illustrations of your genome. Lasergene Core Suite is available in four configurations, each designed with different researchers in mind. The Lasergene Core Suite consists of all ten Lasergene applications: SeqBuilder - for sequence editing and annotation, automated virtual cloning, and primer design SeqMan Pro- for contig assembly and analysis, including SNP discovery, coverage evaluation, and project annotation MegAlign - for DNA and protein sequence alignments and analysis GeneQuest - for gene discovery and annotation Protean 3D - for exploring macromolecular structure, motion, and function Protean - for protein structure analysis and prediction SeqNinja - for advanced editing of genome sequences and annotations GenVision - for publication-quality illustrations PrimerSelect - for primer design EditSeq - for importing and editing unusual file types

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Description: QSeq is DNASTARs next-gen application for RNA-Seq, ChIP-Seq, and miRNA alignment and analysis. QSeq is fully integrated with ArrayStar, enabling you to take advantage of its powerful visualization and analytical tools, including using Gene Ontology (GO) annotations for ontology comparisons and gene characterization. Using QSeq, researchers can select gene sets and export associated reads through the rest of the DNASTAR software pipeline for sequence assembly, alignment, and detailed analysis.

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Description: Since OligoEngine introduced the industry's first siRNA sequence design software in 2001, we have constantly strived to keep these tools consistent with new experimental strategies and published research reports in the field of RNAi. With the introduction of our new, enhanced, and expanded RNAi design tools, OligoEngine is pleased to offer the most significant advancement in RNAi research software. Even with all the inprovements, the OligoEngine platform remains a resource to both commercial and academic researchers, who can use the Web-based (or download-able) software to design and order custom synthesis products for RNAi experiments.

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Description: Partek Genomics Solution is a comprehensive suite of advanced statistics and interactive data visualization specifically designed to reliably extract biological signals from noise. Designed for high-dimensional genomic studies containing thousands of samples, Partek Genomics Solution is fast, memory efficient and will analyze large data sets on a personal computer. It supports a complete workflow including convenient data access tools, identification, and annotation of important biomarkers, and construction and validation of predictive diagnostic classification systems.

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Catalog Number: GM-001
Description: GeneMarker® software has been designed and created in order to provide genetic researchers with a biologist friendly genotyping analysis tool. We incorporated the suggestions and requirements of several research groups into the software. Their main requirements were ease- of- use, high accuracy, flexibility and low acquisition cost. GeneMarker® can perform analysis on up to 1,000 lanes of four or five color data sets generated by either slab gel or capillary electrophoresis. It is a unique genotyping tool as it is compatible with files from all major capillary and slab gel electrophoresis systems including ABI files (*.FSA, .*AB1, *.ABI), SCF files, MegaBace files (*.RSD, *.ESD), SpectruMedix files (*.SMD, *.SMR), Beckman files, and Licor files. GeneMarker® is a replacement for such software packages as SAGA from LI-COR, TrueAllele from Cybergenetics, GeneMapper, Genotyper, and GeneScan from Applied Biosystems.

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Catalog Number: ME-001
Description: Mutation Explorer® processes up to 48 lanes, 24 bi-directional, of patient DNA sequence traces. Data input can be from either slab gel or capillary sequencers, using either terminator or primer chemistries. The detection parameters in Explorer have been “sealed” to provide analyst to analyst consistency. We have built Explorer for ease of use, and quick learning. Normal operation involves only two steps: data input, (Genbank, references and patient traces) followed by review of the differences of the patient to reference as indicated in the mutation electropherogram. Most analysts have found, after becoming familiar with the program’s performance, that peak to peak review of the traces is no longer necessary. The software automatically forms contigs, performs alignments and mutation detection comparing both forward and reverse patient traces to reference or normal traces. Homozygote and Heterozygote mutations are indicated by sharp peaks in our exclusive mutation electropherogram.

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Catalog Number: MS-001
Description: Researchers no longer need to perform time consuming and inaccurate comparison of the entire sample trace. With Mutation Surveyor™, any found variants of the sample when compared to the wild type are clearly indicated in our mutation electropherogram as a sharp peak. Accuracy of the software in the bi-directional analysis mode is over 99%, with sensitivity to greater than 5% of the primary peak. Our collaborators have demonstrated an accuracy of 95% when processing single direction sequence traces. Mutation Surveyor’s™ detection sensitivity has been enhanced to report similar peaks that are buried in baseline noise of both the forward and reverse traces, alerting researchers to the possible presence of mutations buried in the background noise. Mutation Surveyor™ easily processes 400 lanes of data in approximately two minutes, and can be operated on a fully automated unattended basis. The software automatically forms contigs, performs alignments and mutation detection comparing both forward and reverse patient traces to reference or normal traces. Homozygote and Heterozygote mutations are indicated by sharp peaks in our exclusive mutation electropherogram. Unique algorithms perform a comparison of sample to reference traces in both forward and reverse electropherograms checking for similar peaks that are present in the background. This technique provides almost analytical quality sensitivity.

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