Library Screening Services

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High-Throughput High-Content RNAi Screens

High-Throughput High-Content RNAi Screens

Cenix BioScience GmbH

  • Catalog Number: HT/HC-custom
  • Description: Cenix is an industry leader in performing fully customizable high-throughput RNAi Screens in transformed or primary cell models. Since 1999, our well-established core capabilities in high-throughput RNAi screening together with fluorescent reader-based and high-content microscopy-based assays have yielded optimized protocols in a broad and ever-growing collection of cultured cell models, covering a wide range of disease fields including oncology, cardiovascular, metabolic, neurological and infectious diseases. Please contact us to learn how we can add value and efficiency to your next screening project.
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miRNA Inhibitor Library Screening, miRNA Mimic Library Screening

miRNA Inhibitor Library Screening, miRNA Mimic Library Screening

Cenix BioScience GmbH

  • Catalog Number: miR-custom
  • Description: Using up-to-date microRNA inhibitor and mimic libraries, Cenix offers cell-based miRNA Screening, for miRNA target or biomarker discovery and validation. Built upon our long-standing expertise in combining high-throughput RNAi screening with high-content multi-parametric assays, we now offer miRNA modulator screens and/or tandem siRNA/miRNA screens in a range of cell models including adult stem cells. To learn more about how Cenix can help you with your miRNA screening project, please contact us.
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siRNA Screening, siRNA Library Screening

siRNA Screening, siRNA Library Screening

Cenix BioScience GmbH

  • Catalog Number: siRNA-custom
  • Description: Cenix offers fully customizable siRNA Screens covering a broad range of disease fields including oncology, cardiovascular, metabolic, neurological and infectious diseases, and using transformed or primary human or rodent cell models. Whether focused on a handful of target genes, a certain target class or a genome-wide screen, our 11+ years of well-established core capabilities in high-throughput siRNA screening in combination with multi-parametric microscopy assays have resulted in optimized protocols in a broad and ever-growing collection of cultured cell models. Please contact us to discuss the details of your screening needs.
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Custom made highly complex, domain libraries

Custom made highly complex, domain libraries

Hybrigenics Services SAS

  • Catalog Number: Discover-Library
  • Description: Our libraries are the most complex ones available on the market and ULTImate Y2H™ cell-to-cell mating is the only screening technology that can screen them exhaustively. Should you not find your favourite library among our 60+ libraries, we would be happy to construct it for you.

    Our ULTImate Y2H domain libraries are validated by extremely stringent quality controls:

    • Verifying a complexity of at least 10 million independent, primary fragments in yeast for Random-Primed cDNA libraries. The complexity of the genomic libraries (constructed for organisms that contain no or few introns) depends on the size of the genome (e.g. 2 million genomic fragments for Helicobacter pylori library)
    • Random sequencing of 192 clones to check for i) absence of contamination, ii) that ribosomal RNA, mitochondrial DNA and empty vectors represent less than 10% of the total sequences
    • Verifying the viability and mating properties of the library-containing yeast cells, and defining the conditions to obtain the highest mating efficiency (Patent US No 6,187,535)
    • Reproducing selected Y2H screen interactions available from the literature.
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