The 2320EXT incorporates superior pressure and temperature control for the next generation of high pressure sample preparation. Like the NEP2320-ENH, the 2320EXT is a compact, bench top instrument that can process up to 16 samples simultaneously using PCT MicroTubes. Improvements that come standard with the 2320EXT include: increased pressure and temperature ranges to support unparalleled protein extraction from fresh, frozen, and FFPE-treated tissues; data input and output options to accommodate validation and quality control; a choice of two different methods for temperature control (an external circulating waterbath or a built-in electric heater); computer-operated control with touch screen programming and automatic data logging; and the ability to control multiple pressure cycling parameters, such as the rate of pressure increase/decrease, both the high and low pressure levels, and the shape of the pressure profile (e.g., sine wave, square wave, and others), ideal for basic research.