In this Bench Tip Video, Dr. Mike Okimoto discusses CRISPR/Cas genome editing technology. CRISPR technology can be used to quickly and efficiently edit and manipulate a genomic locus in many different cell types and organisms. It can be used for a variety of genome modifications including gene deletion or knockout, knock-in, and knockdown. Watch this video to learn how to set up a CRISPR experiment and the applications of CRISPR technology.