DNA Shearers / DNA Shearing

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Bioruptor® NGS sonication device with 0.5/0.65 ml tube holder, Water Cooler & solenoid valve connections

Diagenode

Catalog Number:
Description: The Bioruptor® NGS is the perfect tool for NGS library preparation. This cutting-edge sonication device is dedicated exclusively to DNA shearing and provides you suitable DNA for unbiased library preparation prior to next generation sequencing. You will obtain your fragmented DNA up to five times faster than with other standard fragmentation devices.

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E220 High Performance Ultrasonicator

Covaris, Inc.

Catalog Number: 500295
Description: The E220 Ultra sonicator reproducibly shears DNA to desired lengths, in multi-sample mode in either plates and tubes. The E220 is optimized for next-gen nucleic acid sequencing and is endorsed by all leading next-gen sequencing suppliers. The E220 is used in all major genome centers worldwide and utilizes proven industry-standard Covaris Adaptive Focused Acoustic™ AFA™ technology to precisely shear DNA samples. As part of Covaris family of instruments, the E220 (and E220x high power) instruments provide multi-sample preparation with scalable acoustic energy, capable of processing a wide range of sample types and volumes. Both instrument versions process from 1 to 96 samples in a single batch. They can be operated in stand-alone mode or can be easily integrated as part of an automated laboratory system. In either configuration, the E-series provides world-class AFA™ sample preparation technology to our customers. The Covaris™ E220™ high-performance focused ultra-sonicators deliver industry leading sample processing capability directly to the benchtop in a scalable, multi-sample format. Our highly efficient and reproducible sample preparation, utilizing AFA technology, eliminates operator induced variation, improves recoveries, increases efficiency, and provides standardized results.

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g-TUBE

Covaris, Inc.

Catalog Number: 520079
Description: The g-Tube from Covaris represents a breakthrough in longer-length DNA shearing technology. The g-TUBE is a single-use-consumable that reliably and reproducibly shears DNA to lengths ranging from 7KB to 12KB. g-TUBE is a single-use device that shears genomic DNA into selected fragments sizes ranging from 6kb to 20kb. The only equipment needed is a compatible bench-top centrifuge. g-TUBE uses centrifugal force (the "g" in g-TUBE) to push the sample through a precisely manufactured orifice. This produces shearing forces in the sample that fragment the DNA. Fragment size is selected by adjusting the centrifuge rotor speed which alters the flow rate through the orifice and thus the shearing forces. Higher centrifugation RPM will produce shorter fragments and the protocol provided by Covaris contains the settings to generate fragment distributions centered on 6, 8, 10 or 20 kbp. The entire process takes only 3 minutes and up to 24 samples can be processed simultaneously with a high reproducibility.

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LE220 High Performance Ultrasonicator

Covaris, Inc.

Catalog Number: 500295
Description: The LE220 Ultra sonicator reproducibly shears DNA to desired lengths, in a multi-sample parallel-processing mode.The LE220 is specifically designed for next-gen nucleic acid sequencing that requires a Covaris AFA solution in a higher throughput format. The LE220 utilizes proven industry-standard Covaris Adaptive Focused Acoustic™ AFA™ technology to concurrently shear multiple DNA samples. In a 96 well microplate or tube array, a row of 8 samples is processed simultaneously by the line transducer in the LE220. By indexing across all 12 rows, the 96 samples are actually processed 8X faster than with a single-sample instrument. The LE220 can process a wide variety of sample formats (including 24, 48, 96, 384 and beyond) an entire row at a time. The Covaris non-contact AFA process focuses high frequency acoustic energy into a small, well defined zone within the sample vessel to create rapid and very complete sample processing. Covaris AFA technology eliminates operator induced variation, improves recoveries, increases efficiency and provides reproducible standardized results.

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M220 High Performance Ultrasonicator

Covaris, Inc.

Catalog Number: 500295
Description: The M220 AFA™ Ultrasonicator is designed for Next-Gen Sequencing applications requiring fragment sizes between 200bp and 3kb. Compact size and ease-of-use make the M220 Personal Fragmenter the ideal DNA shearing solution for MiSeq™ and PGM™ users. Benefits The M220 runs a variety of DNA shearing protocols with Covaris SonoLab 7 software and uses both the Covaris microTUBE™ & miniTUBE™. Integrated temperature control within the M220 eliminates the need for an external chiller, saving space and cost. Covaris AFA (Adaptive Focused Acoustics™) How It Works transmits acoustic energy at ultrasonic frequencies (>400KHz) and very short wavelengths (~3mm) and is uniquely able to focus the energy into your sample. AFA controls the shearing forces that fragment nucleic acids to the selected size. The process is isothermal, non contact, and quiet. Covaris AFA technology in the M220 eliminates operator induced variations, improves recoveries, increases efficiency, and provides standardized results.

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S220 High Performance Ultrasonicator

Covaris, Inc.

Catalog Number: 500295
Description: The S220 Ultra sonicator reproducibly shears DNA to desired lengths, in single-sample mode. The S220 is optimized for next-gen nucleic acid sequencing and is endorsed by all leading next-gen sequencing suppliers. The S220 is used in all major genome centers worldwide. The S220 utilizes proven industry-standard Covaris Adaptive Focused Acoustic™ AFA™ technology to precisely shear DNA samples. The S-series is also capable of extremely rapid and complete homogenization, tissue disruption and sample extraction. As part of Covaris family of instruments, the S220 (and S220x high power) provide single-tube sample preparation with scalable acoustic energy, capable of processing a wide range of sample types and volumes. The S220 can be operated in stand-alone mode or can be easily integrated as part of an automated laboratory system. In either configuration, the S220 provides world-class AFA™ sample preparation technology to our customers. Covaris™ S220 high performance focused ultra-sonicators deliver industry leading sample processing capability directly to the benchtop. The new S-series is a workstation-based instrument capable of extremely rapid and complete shearing, homogenization, tissue disruption and sample extraction. Our highly efficient, and reproducible sample preparation, utilizing the proprietary Covaris Adaptive Focused Acoustic (AFA) technology, eliminates operator induced variation, improves recoveries, increases efficiency, and provides standardized results.

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Bioruptor® NGS sonication device with 0.5/0.65 ml tube holder, Water Cooler & solenoid valve connections

Diagenode

Catalog Number: UCD-600-TS
Description: The Bioruptor® NGS is the perfect tool for NGS library preparation. This cutting-edge sonication device is dedicated exclusively to DNA shearing and provides you suitable DNA for unbiased library preparation prior to next generation sequencing. You will obtain your fragmented DNA up to five times faster than with other standard fragmentation devices.

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Bioruptor® Plus with accessories for 6 x 1.5 ml and 6 x 15 ml tubes & water cooler & solenoid valve connections

Diagenode

Catalog Number: UCD-300 TO
Description: The Bioruptor® uses a unique system to uniformely process multiple samples in sealed tubes of 0.5ml to 50ml capacity. An excellent device for shearing chromatin or DNA, cell lysis and many other applications.

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Bioruptor® Plus with accessories for 6 x 1.5 ml tubes & water cooler & solenoid valve connections

Diagenode

Catalog Number: UCD-300 TM
Description: The Bioruptor® uses a unique system to uniformely process multiple samples in sealed tubes of 0.5ml to 50ml capacity. An excellent device for shearing chromatin or DNA, cell lysis and many other applications.

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Bioruptor® Standard sonication device with 1.5 & 15 ml tube holder & new soundproof box

Diagenode

Catalog Number: UCD-200 TO
Description: The Bioruptor® uses a unique system to uniformly process multiple samples in sealed tubes of 0.5ml to 50ml capacity. An excellent device for shearing chromatin or DNA, cell lysis and many other applications.

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Bioruptor® Standard sonication device with 1.5 ml tube holder & new soundproof box

Diagenode

Catalog Number: UCD-200 TM
Description: The Bioruptor® uses a unique system to uniformly process multiple samples in sealed tubes of 0.5ml to 50ml capacity. An excellent device for shearing chromatin or DNA, cell lysis and many other applications.

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Bioruptor® Twin with accessories for 12 x 1.5 ml and 6 x 15 ml tubes, water cooler & valve kit

Diagenode

Catalog Number: UCD-400 TO
Description: The Bioruptor® uses a unique system to uniformely process multiple samples in sealed tubes of 0.5ml to 50ml capacity. An excellent device for shearing chromatin or DNA, cell lysis and many other applications.

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Bioruptor® Twin with accessories for 12 x 1.5 ml tubes, water cooler & valve kit

Diagenode

Catalog Number: UCD-400 TM
Description: The Bioruptor® uses a unique system to uniformely process multiple samples in sealed tubes of 0.5ml to 50ml capacity. An excellent device for shearing chromatin or DNA, cell lysis and many other applications.

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Bioruptor® Water Cooler - including continuous valve for Bioruptor®

Diagenode

Catalog Number: BioAcc-Cool
Description: This water cooling system allows for continous cooling of the Bioruptor® waterbath. An additional regulating valve (Valve kit) ensures that water will only be replaced during the off cycle to avoid any interference between water flow and the sonication process.

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Bioruptor® XL with accessories for 24 x 1.5 ml tubes & water cooler

Diagenode

Catalog Number: UCD-500 TM
Description: The Bioruptor® uses a unique system to uniformely process multiple samples in sealed tubes of 0.5ml to 50ml capacity. An excellent device for cell lysis.

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Bioruptor® XL with with accessories for 24 x 1.5 ml, 24 x 15 ml tubes & water cooler

Diagenode

Catalog Number: UCD-500 TO
Description: The Bioruptor® uses a unique system to uniformely process multiple samples in sealed tubes of 0.5ml to 50ml capacity. An excellent device for cell lysis.

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Shearing ChIP kit for 18 IPs

Diagenode

Catalog Number: kch-redmod-100
Description: The first critical step of a successful ChIP experiment is the preparation of sheared Chromatin. We therefore suggest the use one of our optimized Shearing ChIP kits.

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Shearing ChIP kit for 72 IPs

Diagenode

Catalog Number: kch-redmod-400
Description: The first critical step of a successful ChIP experiment is the preparation of sheared Chromatin. We therefore suggest the use one of our optimized Shearing ChIP kits.

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Shearing Optimization kit for 75 IPs

Diagenode

Catalog Number: kch-shchro-040
Description: The first critical step of a successful ChIP experiment is the preparation of sheared Chromatin. We therefore suggest the use one of our optimized Shearing ChIP kits.

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dsDNA Fragmentase NEBNext™

New England Biolabs

Catalog Number: M0348L
Description: Inquire

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dsDNA Fragmentase NEBNext™

New England Biolabs

Catalog Number: M0348S
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