Articles in this Issue

• High Throughput, Label-free Screening Small Molecule Compound Libraries for Protein-Ligands...

  James P. Landry, Ph.D., Yiyan Fei, Ph.D., Xiangdong Zhu, Ph.D.
  Small-molecule compounds remain the major source of therapeutic and preventative drugs. Developing new drugs against a protein target often requires screening large collections of compounds with diverse structures for ligands or ligand fragments that... read more

• RNAi Therapy: Involving the Immune System

  Nigel A J McMillan, Norliana Khairuddin, Ph.D
  RNA interference (RNAi) is a powerful tool for gene silencing. Over the past decade our increased understanding of the molecular mechanisms underlying RNAi has provided an avenue towards utilizing it therapeutically. Of the many RNAi precursors, ... read more

• Innovations from Materials Science to Improve Biological Fluorescence

  Marcel P. Bruchez, Ph.D.
  Many innovations in materials chemistry have been developed to improve the performance of photovoltaic and light-emitting devices. Although the major target of these advances is not biological, we have adapted a number of materials advances to ... read more

• TET Inhibitors as Potential New Cancer Drugs - An Enzyme that Converts 5-methylcytosine to...

  Nancy Chia
  The Ten-eleven translocation (TET) protein family is a well-conserved group of proteins consisting of TET1, TET2, and TET3 members that have various roles in gene expression by converting 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) in ... read more