Using Affymetrix Axiom World Arrays for genome-wide and HLA association analyses of childhood acute lymphoblastic leukemia
Dr. Adam de Smith
Monday, October 31, 2016
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Chapters
Introduction
Outline
Childhood ALL
Natural History ALL
Genetic Risk Factors
The HLA complex
HLA and childhood ALL
1. GWAS of childhood ALL in the CCRLP
GWAS of childhood ALL
2. HLA imputation and association analyses
HLA imputation using Axiom™ HLA Analysis Tool
HLA imputation of childhood ALL SNP data
HLA IMP: 02 output
Control HLA locus frequencies
Allele association results
Next steps
3. GWAS of ALL in children with Down syndrome
Summary
Acknowledgement
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