ATCC Molecular Signature Panels – Powerful tools for the genomics age
Wednesday, January 15, 2014
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Chapters
Introduction
Who we are
Outline
NGS leads to genomic age
Somatic mutations in cancer
The changing landscape
ATCC Tumor Cell Panels
ATCC Molecular Signature Cell Panels
Molecular Signature Cell Panels
EGFR introduction
EGFR cell panel characteristics
EGFR cell panel mRNA expression
EGFR Cell Panel Protein Expression
EGFR Cell Panel IF staining
EGFR panel cell growth kinetics
EGFR cell panel culture conditions
EGFR panel cell morphology
PI3k pathway
PIK3CA Mutation Cells Lines and Panel
Genetic alterations affect drug sensitivity
ERK somatic mutations
ERK Genetic Alteration Panel
Recommended control
Molecular signature panels to facilitate novel anti-cancer drug discovery
Tumor heterogeneity
Using authenticated cell lines as controls
KRAS mutation CRM cell lines and DNAs
Some useful cell line databases
Conclusion
Q&A
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