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  • Transcriptome Analysis: Microarrays, qPCR and RNA-Seq

    Transcriptome Tools

    Tuesday, May 21, 2013
    Transcriptomics studies attempt to catalog and quantify the RNA content of a cell, tissue or organism. There essentially are three techniques for ... read more
  • Differential Expression Analysis of RNA-Seq Data

    RNA-Seq and the Transcriptome

    Tuesday, May 07, 2013
    RNA-Seq builds on next-generation DNA sequencing (NGS), taking as its input RNA that has been reverse-transcribed into cDNA and (usually) PCR-... read more
  • Whole Genome Sequencing Technologies Enhance Speed and Throughput

    Whole Genome Sequencing’s Speedy Pace

    Thursday, April 25, 2013
    Whole-genome sequencing (WGS) can sequence an entire genome at once, and it is advancing quickly enough to sequence a whole genome in about 24 hours. ... read more
  • Biomarker Analysis: The Intersection of Research and Healing

    Biomarker Analysis

    Tuesday, April 23, 2013
    The very nature of biomarkers can affect how they [perform] and how they should be analyzed, yet there are wide variations in biomarker types, ... read more
  • The Cytogenetics Toolbox: Techniques to Study DNA from the Single Nucleotide to the Chromosomal Level

    The Cytogenetics Toolbox

    Thursday, April 11, 2013
    As cells grow and divide, their genetic material acquires changes. Sometimes those are single-base changes, and othertimes, those changes occur on a ... read more
  • A Sequence of Expression

    A Sequence of Expression

    Tuesday, April 02, 2013
    In short, our understanding genomics continues to rapidly evolve. While traditional, well-established techniques are still prevalent and powerful, ... read more
  • Exome Sequencing Comes of Age

    Exome Sequencing Comes of Age

    Tuesday, March 12, 2013
    In effect, exome sequencing is just a special form of targeted sequencing, an application in which researchers capture specific genomic segments for ... read more
  • Mining Genetic Variation: The Latest SNP Analysis Tools

    Mining Genetic Variation: The Latest SNP Analysis Tools

    Wednesday, February 27, 2013
    As their name suggests, single nucleotide polymorphisms (SNPs) are single-base sites of variation between peoples’ genomes, and they are, by far, the ... read more
  • Next Generation Sequencing 2013: Looking Into Genomes

    NGS 2013: Looking Into Genomes

    Tuesday, January 29, 2013
    Next Gen Sequencing firms continue to optimize their hardware, software, and reagents to squeeze ever more bases from their instruments ever more ... read more
  • Transcriptomics: From Microarrays to RNA-Seq

    Transcriptomics: From Microarrays to RNA-Seq

    Tuesday, January 08, 2013
    RNA-Seq has largely solved many of the problems posed when using microarrays in transcriptome studies. By sequencing all the transcripts in a sample ... read more
  • Transcriptome Analysis Using RNA-Seq

    Transcriptome Analysis Using RNA-Seq

    Tuesday, September 04, 2012
    Today, transcriptome analysis is performed most commonly using an NGS application called RNA-seq, in which an RNA pool is reverse-transcribed into ... read more
  • The Role of Non-coding RNAs in Epigenetics

    The Role of Non-coding RNAs in Epigenetics

    Sunday, April 01, 2012
    How does the cell direct those epigenetic modifications to where they are needed? The answer seems to involve a class of RNAs called long non-coding ... read more
  • Next Generation Sequencing

    Next Generation Sequencing

    Tuesday, November 29, 2011
    New low-cost instruments, including Life Technologies’ low-cost Ion Torrent PGM and Illumina’s MiSeq, have made next-gen sequencing a possibility for ... read more
  • Chromatin Immunoprecipitation (ChIP) Assays

    Chromatin Immunoprecipitation (ChIP) Assays

    Monday, August 29, 2011
    Suppose you identify a transcription factor that you believe regulates some gene of interest. It’s easy enough to demonstrate this protein is capable ... read more