Editorial Articles

  • FFPE or Frozen? Working with Human Clinical Samples

    Working with Human Clinical Samples

    Friday, November 07, 2014
    Peering into human tissues—to study morphology, cell biology, biochemistry and more—is made possible using sections of biopsied tissue that have been ... read more
  • Probe Your Proteome with These Quantitative Mass Spec Tools

    Quantitative Proteomics

    Friday, September 26, 2014
    The defining tool of proteomics research is the mass spectrometer, and it has been for years. But the way that tool is used has changed. Today, there'... read more
  • Marked for Destruction? Find Out with These Ubiquitination Tools

    Purifying Ubiquitinated Proteins

    Tuesday, September 23, 2014
    Isolating ubiquitinated proteins is usually accomplished using affinity purification, using antibodies or binding domains. Here is a look at your ... read more
  • Laboratory Developed Tests: The Cutting Edge of Molecular Diagnostics

    Laboratory Developed Tests

    Thursday, July 24, 2014
    Although faster and less expensive to develop than FDA-approved diagnostics, laboratory-developed tests do have standards they must adhere to. Here ... read more
  • Let Your Westerns Ride Off Into the Sunset, Multiplex Protein Quant with SRM Instead

    Protein Quantitation with SRM

    Tuesday, June 24, 2014
    For higher levels of multiplexing, researchers in the proteomics community increasingly are keeping their antibodies in the freezer and warming up ... read more
  • Know Your Microbes with These Pathogen Characterization Tools

    Pathogen Detection Tools

    Tuesday, June 17, 2014
    Breaking the cycle of antibiotic resistant bacteria requires correctly identifying and characterizing pathogens as early as possible, then treating ... read more
  • Squeeze More From Your Sample with Multiplexed PTM Assays

    Multiplexed PTM Analysis

    Friday, June 13, 2014
    Phosphoproteins are most commonly detected by antibodies, either in Western blots or ELISA formats. Yet these assays do not traditionally lend ... read more
  • Indulge Your Molecular Sweet-Tooth with Glycoprotein Analysis Tools

    Glycoprotein Analysis

    Thursday, May 22, 2014
    As tools to recognize and analyze the carbohydrates (called glycans) that decorate proteins are improving, researchers are becoming ever more ... read more
  • Break the Metabolomics Bottleneck with These Data Analysis Tools

    Metabolomics Data Analysis

    Thursday, May 15, 2014
    As with other ‘omics disciplines, data collection is only one and certainly not the greatest problem metabolomics practitioners face. The bigger ... read more
  • LC-MS at the Nanoscale

    LC-MS at the Nanoscale

    Tuesday, May 06, 2014
    Researchers often separate and identify molecules in a mixture using liquid chromatography-coupled mass spectrometry (LC-MS). Nano-LC-MS is a variant ... read more
  • Add a Molecular Dimension to Your Tissue Slices with Imaging Mass Spectrometry

    Imaging Mass Spectrometry

    Thursday, April 17, 2014
    Imaging Mass Spectrometry scans a tissue section point by point, amassing a dataset that correlates molecular species with their spatial positions. ... read more
  • Get the Big Picture with Top-Down Proteomics

    Top-Down Proteomics

    Thursday, January 23, 2014
    Proteomics can be bottom-up or top-down. The former is easier, the latter, more comprehensive -- especially when it comes to distinguishing one "... read more
  • Protein Biomarker Discovery Tools

    Protein Biomarker Discovery Tools

    Wednesday, November 27, 2013
    While probing the genome certainly provides some leads as to the likelihood of disease development, it is protein biomarkers that speak to the here ... read more
  • Focus on Your Desired Cellular Compartment with These Cell Fractionation Tools

    Cell Fractionation Tools

    Tuesday, November 26, 2013
    Researchers fractionate cells for many reasons, from tracking protein translocation, to simplifying downstream analyses, to enhancing detection of low... read more
  • Post-Translational Modifications: Finding the Needle in the Molecular Haystack

    Post-Translational Modification Analysis

    Thursday, September 19, 2013
    In theory, sample purification for studying post-translational modifications isn’t really all that different from any other project. But you do need ... read more
  • How to Keep Your Chromatography Column in Tip-Top Shape

    A Little TLC For Your HPLC

    Thursday, August 01, 2013
    Keeping chromatography columns in tip-top condition will go a long way not only toward improving and standardizing your separations but also ensuring ... read more
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