Editorial Articles

  • Let Your Westerns Ride Off Into the Sunset, Multiplex Protein Quant with SRM Instead

    Protein Quantitation with SRM

    Tuesday, June 24, 2014
    For higher levels of multiplexing, researchers in the proteomics community increasingly are keeping their antibodies in the freezer and warming up ... read more
  • Know Your Microbes with These Pathogen Characterization Tools

    Pathogen Detection Tools

    Tuesday, June 17, 2014
    Breaking the cycle of antibiotic resistant bacteria requires correctly identifying and characterizing pathogens as early as possible, then treating ... read more
  • Squeeze More From Your Sample with Multiplexed PTM Assays

    Multiplexed PTM Analysis

    Friday, June 13, 2014
    Phosphoproteins are most commonly detected by antibodies, either in Western blots or ELISA formats. Yet these assays do not traditionally lend ... read more
  • Indulge Your Molecular Sweet-Tooth with Glycoprotein Analysis Tools

    Glycoprotein Analysis

    Thursday, May 22, 2014
    As tools to recognize and analyze the carbohydrates (called glycans) that decorate proteins are improving, researchers are becoming ever more ... read more
  • Break the Metabolomics Bottleneck with These Data Analysis Tools

    Metabolomics Data Analysis

    Thursday, May 15, 2014
    As with other ‘omics disciplines, data collection is only one and certainly not the greatest problem metabolomics practitioners face. The bigger ... read more
  • LC-MS at the Nanoscale

    LC-MS at the Nanoscale

    Tuesday, May 06, 2014
    Researchers often separate and identify molecules in a mixture using liquid chromatography-coupled mass spectrometry (LC-MS). Nano-LC-MS is a variant ... read more
  • Add a Molecular Dimension to Your Tissue Slices with Imaging Mass Spectrometry

    Imaging Mass Spectrometry

    Thursday, April 17, 2014
    Imaging Mass Spectrometry scans a tissue section point by point, amassing a dataset that correlates molecular species with their spatial positions. ... read more
  • Get the Big Picture with Top-Down Proteomics

    Top-Down Proteomics

    Thursday, January 23, 2014
    Proteomics can be bottom-up or top-down. The former is easier, the latter, more comprehensive -- especially when it comes to distinguishing one "... read more
  • Protein Biomarker Discovery Tools

    Protein Biomarker Discovery Tools

    Wednesday, November 27, 2013
    While probing the genome certainly provides some leads as to the likelihood of disease development, it is protein biomarkers that speak to the here ... read more
  • Focus on Your Desired Cellular Compartment with These Cell Fractionation Tools

    Cell Fractionation Tools

    Tuesday, November 26, 2013
    Researchers fractionate cells for many reasons, from tracking protein translocation, to simplifying downstream analyses, to enhancing detection of low... read more
  • Post-Translational Modifications: Finding the Needle in the Molecular Haystack

    Post-Translational Modification Analysis

    Thursday, September 19, 2013
    In theory, sample purification for studying post-translational modifications isn’t really all that different from any other project. But you do need ... read more
  • How to Keep Your Chromatography Column in Tip-Top Shape

    A Little TLC For Your HPLC

    Thursday, August 01, 2013
    Keeping chromatography columns in tip-top condition will go a long way not only toward improving and standardizing your separations but also ensuring ... read more
  • GC-MS: The yin to LC-MS's yang

    The ups and downs of GC-MS

    Thursday, June 06, 2013
    GC-MS is the yin to LC-MS’s yang. Where LC-MS is solvent-based, GC-MS is a gas-phase technique. As a result, LC-MS is ideal for peptides, drugs, and ... read more
  • Lipidomics: A Decade of Growth

    Lipidomics: A Decade of Growth

    Tuesday, June 04, 2013
    Though once regarded largely as cellular junk, material to be eliminated before getting to the more interesting proteins and nucleic acids, lipids are... read more
  • Striking the Right Balance for Protein Extraction

    Conquering Cells to Extract the Proteins Within

    Tuesday, May 28, 2013
    When it comes to protein extraction, it’s all about balance: You need a method strong enough to crack open the cell wall and/or membrane, yet gentle ... read more
  • Picking Apart PAGE: An Overview of Protein Gel Electrophoresis

    Protein Separation via PAGE for Multiple Applications

    Tuesday, April 30, 2013
    An overview of protein gel electrophoresis prior to Western blotting, mass spec, and other applications. read more