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  • Detecting Copy-Number Variation at High Resolution

    High-res CNV Detection

    Thursday, June 13, 2013
    Traditionally, geneticists identified CNVs using fluorescence in situ hybridization (FISH) and early microarrays, but those methods had limited ... read more
  • Transcriptome Analysis: Microarrays, qPCR and RNA-Seq

    Transcriptome Tools

    Tuesday, May 21, 2013
    Transcriptomics studies attempt to catalog and quantify the RNA content of a cell, tissue or organism. There essentially are three techniques for ... read more
  • Transcriptomics: From Microarrays to RNA-Seq

    Transcriptomics: From Microarrays to RNA-Seq

    Tuesday, January 08, 2013
    RNA-Seq has largely solved many of the problems posed when using microarrays in transcriptome studies. By sequencing all the transcripts in a sample ... read more
  • The Role of Non-coding RNAs in Epigenetics

    The Role of Non-coding RNAs in Epigenetics

    Sunday, April 01, 2012
    How does the cell direct those epigenetic modifications to where they are needed? The answer seems to involve a class of RNAs called long non-coding ... read more
  • Genomic DNA preparation kits

    Genomic DNA preparation kits

    Monday, April 11, 2011
    The dawn of the kit era, when everything you needed for a routine yet important lab task could be conveniently purchased in a box, made life easier ... read more
  • Copy Number Analysis

    Copy Number Analysis

    Wednesday, August 04, 2010
    Copy number analysis is beginning to supplement or replace older forms of genomic analysis such as SNP analysis and microarray analysis. New ... read more
  • Sequence Capture

    Sequence Capture

    Wednesday, July 14, 2010
    Ten years after the first draft human genome was announced, genomic science is finally beginning to pay dividends in the healthcare arena. A few ... read more
  • Nuclear Receptors: Bringing The Outside World in

    Nuclear Receptors: Bringing The Outside World in

    Wednesday, April 21, 2010
    The power of nuclear receptors should not be underestimated. However, we have yet to understand fully how these fascinating molecules work, though we ... read more
  • DNA Methylation and Cancer

    DNA Methylation and Cancer

    Wednesday, April 14, 2010
    The classical view of cancer was of a progressive series of mutations conferring growth advantages, such that the cell is no longer constrained by the... read more
  • Transcriptome Analysis

    Transcriptome Analysis

    Wednesday, March 17, 2010
    There's change in the air in the world of transcriptome analysis. Once the domain of microarrays, transcriptome analysis (that is, gene expression ... read more
  • Microarray Instrumentation & Software

    Microarray Instrumentation & Software

    Monday, March 08, 2010
    The advent of microarray technology enabled massive parallel processing of DNA (or RNA) screening experiments. Made of an orderly set of DNA spots ... read more
  • Pharmacogenomics

    Pharmacogenomics

    Monday, November 02, 2009
    Among the many justifications for the Human Genome Project was the promise of personalized medicine. By sequencing the human genome, the rationale ... read more
  • Ironing Out The Wrinkles In Peptide Microarrays

    Ironing Out The Wrinkles In Peptide Microarrays

    Monday, July 27, 2009
    With DNA microarrays a common tool now, proteomics researchers would like to introduce you to something analogous – peptide microarrays, with which ... read more
  • Protein-DNA Interactions

    Protein-DNA Interactions

    Monday, June 29, 2009
    For all its information, DNA is biologically inert. The cell must work to propagate its genetic information, using RNA polymerases to transcribe genes... read more
  • Molecular Diagnostics

    Molecular Diagnostics

    Monday, June 08, 2009
    There is a great deal of momentum gathering around the field of Molecular Diagnostics, which encompasses a broad range of technologies and therapeutic... read more
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