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MicroRNA Target ID
Tuesday, April 08, 2014
MicroRNAs (miRNAs) affect virtually every aspect of our biology, from cancer to development. Although each of the more than 1,000 known miRNAs can ...
Finding Cancer Biomarkers
Tuesday, April 01, 2014
Cancer researchers are constantly on the lookout for ways to predict disease outcome, determine which therapies are called for and track patient ...
Tuesday, March 11, 2014
For years, molecular cytogeneticists have been limited by the relatively crude tools at their disposal, such as Giemsa staining, FISH and DNA ...
Gene Expression Analysis
Thursday, February 27, 2014
Using next-generation DNA sequencing, cloud computing and in silico design tools, anyone can become expert in the gene expression of organisms outside...
Outsourcing miRNA Analysis
Tuesday, February 18, 2014
For many researchers, microRNA discovery and investigation are more a means to an end than the focus of their research. Or perhaps they simply are ...
Probing Protein-lncRNA Interactions
Tuesday, November 19, 2013
There is considerable research interest in the class of molecules called long noncoding RNAs (lncRNAs). Many have been identified, but few have had ...
Whole Genome Amplification Tools
Thursday, November 14, 2013
Typical next-generation sequencing protocols, for example, call for microgram quantities of starting material, far more than may be obtained from many...
Of Noncoding RNA and Epigenetics
Tuesday, July 23, 2013
Whether long, small or micro, noncoding RNAs are not translated into proteins, yet fulfill important regulatory roles in gene expression. Here we ...
High-res CNV Detection
Thursday, June 13, 2013
Traditionally, geneticists identified CNVs using fluorescence in situ hybridization (FISH) and early microarrays, but those methods had limited ...
Tuesday, May 21, 2013
Transcriptomics studies attempt to catalog and quantify the RNA content of a cell, tissue or organism. There essentially are three techniques for ...
Transcriptomics: From Microarrays to RNA-Seq
Tuesday, January 08, 2013
RNA-Seq has largely solved many of the problems posed when using microarrays in transcriptome studies. By sequencing all the transcripts in a sample ...
The Role of Non-coding RNAs in Epigenetics
Sunday, April 01, 2012
How does the cell direct those epigenetic modifications to where they are needed? The answer seems to involve a class of RNAs called long non-coding ...
Genomic DNA preparation kits
Monday, April 11, 2011
The dawn of the kit era, when everything you needed for a routine yet important lab task could be conveniently purchased in a box, made life easier ...
Copy Number Analysis
Wednesday, August 04, 2010
Copy number analysis is beginning to supplement or replace older forms of genomic analysis such as SNP analysis and microarray analysis. New ...
Wednesday, July 14, 2010
Ten years after the first draft human genome was announced, genomic science is finally beginning to pay dividends in the healthcare arena. A few ...
Nuclear Receptors: Bringing The Outside World in
Wednesday, April 21, 2010
The power of nuclear receptors should not be underestimated. However, we have yet to understand fully how these fascinating molecules work, though we ...
P53/ATM Aquarius Hematology FISH Probe
I am investigating chromosomal aberrations in lymphoma and have used the P53/ATM probe to assess gain and loss of these targets from fresh-frozen imprint slides...
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