Polyacrylamide gel electrophoresis (PAGE) is by far the most prevalent method for the separation and detection of proteins. The first step in performing PAGE analysis is the preparation of the acrylamide gel. Several of the components of PAGE gels contain chemicals that are toxic prior to polymerization, thus handling must incorporate a degree of caution to avoid contact. In response to concerns over potential neurotoxicity related to handling, several manufacturers offer pre-made (also called pre-cast) polyacrylamide gels. Pre-made gels not only eliminate the handling of toxic materials, they also provide a high degree of consistency, particularly when dealing with gradient gels. In addition, the use of pre-made gels results in a significant time savings as the gels are ready immediately, eliminating the need to wait for polymerization. Looking for a way to save time, reduce the handling of toxic chemicals and increase your gel consistency? Read about some of the pre-made polyacrylamide gels listed below and learn about the alternatives.