Mouse TLR Signaling Genes

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pUNO-mIRAK1

InvivoGen

Catalog Number: puno-mirak1
Description: pUNO-mIRAK1 is a sequence-verified expression plasmid containing the murine IL-1R associated kinase 1 Interleukin-1 receptor-associated kinases (IRAKs) are serine/threonine kinases that act as signal transduction mediators for the TLRs. The IRAK family consists of two active kinases, IRAK-1 and IRAK-4, and two inactive kinases, IRAK-2 and IRAK-M. Upon stimulation, the adaptor MyD88 recruits IRAK-1, IRAK-2 and IRAK-4 to the receptor. IRAK-4 then phosphorylates IRAK-1 which dissociates from the receptor and interacts directly with TRAF-6 to relay the signal. Subsequently, IRAK-1 undergoes autophosphorylation followed by degradation. IRAK-4 is an essential component of the IL-1, IL-18 and TLR signaling cascade[2-4].1. Janssens S. & Beyaert R., 2003. Functional diversity and regulation of different interleukin-1 receptor-associated kinase (IRAK) family members. Mol Cell. 11(2):293-302.2. Li S. et al., 2002. IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase.Proc Natl Acad Sci U S A. 99(8):5567-72.3. Lye E. et al., 2004. The role of interleukin 1 receptor-associated kinase-4 (IRAK-4) kinase activity in IRAK-4-mediated signaling. J Biol Chem. 279(39):40653-8.4. Suzuki N et al., 2003. IL-1 receptor-associated kinase 4 is essential for IL-18-mediated NK and Th1 cell responses. J Immunol. 170(8):4031-5. Plasmid is selectable in both mammalian cells and E. coli with Blasticidin.

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pUNO-mIRAK4

InvivoGen

Catalog Number: puno-mirak4
Description: pUNO-mIRAK4 is a sequence-verified expression plasmid containing the murine IL-1R associated kinase 4 Interleukin-1 receptor-associated kinases (IRAKs) are serine/threonine kinases that act as signal transduction mediators for the TLRs. The IRAK family consists of two active kinases, IRAK-1 and IRAK-4, and two inactive kinases, IRAK-2 and IRAK-M. Upon stimulation, the adaptor MyD88 recruits IRAK-1, IRAK-2 and IRAK-4 to the receptor. IRAK-4 then phosphorylates IRAK-1 which dissociates from the receptor and interacts directly with TRAF-6 to relay the signal. Subsequently, IRAK-1 undergoes autophosphorylation followed by degradation. IRAK-4 is an essential component of the IL-1, IL-18 and TLR signaling cascade[2-4].1. Janssens S. & Beyaert R., 2003. Functional diversity and regulation of different interleukin-1 receptor-associated kinase (IRAK) family members. Mol Cell. 11(2):293-302.2. Li S. et al., 2002. IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase.Proc Natl Acad Sci U S A. 99(8):5567-72.3. Lye E. et al., 2004. The role of interleukin 1 receptor-associated kinase-4 (IRAK-4) kinase activity in IRAK-4-mediated signaling. J Biol Chem. 279(39):40653-8.4. Suzuki N et al., 2003. IL-1 receptor-associated kinase 4 is essential for IL-18-mediated NK and Th1 cell responses. J Immunol. 170(8):4031-5. Plasmid is selectable in both mammalian cells and E. coli with Blasticidin.

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pUNO-mIRAKM

InvivoGen

Catalog Number: puno-mirakm
Description: pUNO-mIRAKM is a sequence-verified expression plasmid containing the murine IL-1R associated kinase M Interleukin-1 receptor-associated kinase (IRAK)-M is an inactive kinase found mainly in cells of the monocytic lineage, whereas other IRAKs are ubiquitous. IRAK-M negatively regulates TLR signaling. TLR stimulation induces IRAK-M which in turn down-regulates TLR signaling by preventing the dissociation of IRAK-1 and IRAK-4 from MyD88 and the formation of IRAK-1/TRAF6 complexes. IRAK-M-deficient cells exhibit increased cytokine production upon LPS stimulation and reduced endotoxin tolerance. IRAK-M is also involved in peptidoglycan-induced tolerance.1. Wesche H. et al., 1999. IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family. J Biol Chem, 274(27):19403-10.2. Kobayashi K. et al., 2002. IRAK-M is a negative regulator of Toll-like receptor signaling. Cell, 110(2): 191-202.3. Nakayama K. et al., 2004. Involvement of IRAK-M in peptidoglycan-induced tolerance in macrophages. J Biol Chem. 279(8):6629-34. Plasmid is selectable in both mammalian cells and E. coli with Blasticidin.

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pUNO-mIRF3

InvivoGen

Catalog Number: puno-mirf3
Description: pUNO-mIRF3 is a sequence-verified expression plasmid containing the murine Interferon Regulatory Factor 3 open reading frame. Plasmid is selectable in both mammalian cells and E. coli with Blasticidin.

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pUNO-mIRF5

InvivoGen

Catalog Number: puno-mirf5
Description: pUNO-mIRF5 is a sequence-verified expression plasmid containing the murine Interferon Regulatory Factor 5 open reading frame. Plasmid is selectable in both mammalian cells and E. coli with Blasticidin.

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pUNO-mIRF7

InvivoGen

Catalog Number: puno-mirf7
Description: pUNO-mIRF7 is a sequence-verified expression plasmid containing the murine Interferon Regulatory Factor 7 open reading frame. Plasmid is selectable in both mammalian cells and E. coli with Blasticidin.

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pUNO-mMAP3K7b

InvivoGen

Catalog Number: puno-mmap3k7b
Description: Murine MAP3K7b ORF, provided in a pUNO plasmid. pUNO is a family of plasmids expressing genes involved in TLR signaling. pUNO plasmids are selectable in E. coli and mammalian cells with blasticidin.

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pUNO-mPELI-1

InvivoGen

Catalog Number: puno-mpeli1
Description: Murine PELI-1 ORF, provided in a pUNO plasmid. pUNO is a family of plasmids expressing genes involved in TLR signaling. pUNO plasmids are selectable in E. coli and mammalian cells with blasticidin.

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pUNO-mPELI-2

InvivoGen

Catalog Number: puno-mpeli2
Description: Murine PELI-2 ORF, provided in a pUNO plasmid. pUNO is a family of plasmids expressing genes involved in TLR signaling. pUNO plasmids are selectable in E. coli and mammalian cells with blasticidin.

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pUNO-mPKR

InvivoGen

Catalog Number: puno-mpkr
Description: pUNO-mPKR is a sequence-verified expression plasmid containing the murine Protein Kinase, Interferon-inducible double stranded RNA dependent Protein kinase RNA-regulated (PKR), an ubiquitous serine/threonine kinase that is induced by interferons, is a critical signal transducer implicated in different stress-induced signaling pathways including dsRNA-induced TLR3 signaling and LPS-induced TLR4 signaling[2,3]. Upon stress stimulation, PKR is activated by autophosphorylation and subsequently phosphorylates the alpha-subunit of eukaryotic initiation factor 2 (eIF-2a) thereby inducing apoptosis. PKR mediates the activation of important transcription factors, such as NF-kB, and MAP kinases, such as p382, by interacting with the TAK1 complex.1. Jiang Z. et al., 2003. Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR. J Biol Chem. 278(19):16713-9. 2. Goh KC. et al., 2000. The protein kinase PKR is required for p38 MAPK activation and the innate immune response to bacterial endotoxin. EMBO J. 19(16):4292-7.3. Hsu LC. et al., 2004. The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4. Nature. 2004 Mar 18;428(6980):341-5. Plasmid is selectable in both mammalian cells and E. coli with Blasticidin.

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pUNO-mRIPK1

InvivoGen

Catalog Number: puno-mripk1
Description: Murine RIPK1 ORF, provided in a pUNO plasmid. pUNO is a family of plasmids expressing genes involved in TLR signaling. pUNO plasmids are selectable in E. coli and mammalian cells with blasticidin.

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pUNO-mRIPK2

InvivoGen

Catalog Number: puno-mrick
Description: pUNO-mRIPK2 is a sequence-verified expression plasmid containing the murine Receptor-interacting serine-threonine kinase 2Caspase recruitment domain-containing protein 3 Other aliases: RIP2, CARDIAKReceptor-interacting protein 2 (RIP2), also known as RICK, Rip2, CARDIAK and CARD3, is a serine/threonine kinase characterized by a C-terminal caspase activation and recruitment domain (CARD). Beside caspase activation, RIP2 is implicated in NF-kB activation. It acts as a signal transducer for pattern-recognition receptors, including TLRs and NODs[1-4]. RIP2 is recruited to certain TLR-signaling complexes after ligand stimulation promoting the activation of NF-kB and the production of proinflammatory cytokines. Furthermore, RIP2 is required for optimal TCR signalling and T-cell differentiation. Thus RIP2 is an essential mediator for both the innate and adaptive immune responses.1. Kobayashi K. et al., 2002. RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature 416(6877):194-9.2. Chin AI. et al., 2002. Involvement of receptor-interacting protein 2 in innate and adaptive immune responses. Nature 416(6877):190-4.3. Pauleau AL. & Murray PJ., 2003. Role of nod2 in the response of macrophages to toll-like receptor agonists. Mol Cell Biol. 23(21):7531-9.4. Girardin SE. et al., 2001. CARD4/Nod1 mediates NF-kappaB and JNK activation by invasive Shigella flexneri.EMBO Rep.2(8):736-42. Plasmid is selectable in both mammalian cells and E. coli with Blasticidin.

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pUNO-mRIPK3

InvivoGen

Catalog Number: puno-mripk3
Description: Murine RIPK3 ORF, provided in a pUNO plasmid. pUNO is a family of plasmids expressing genes involved in TLR signaling. pUNO plasmids are selectable in E. coli and mammalian cells with blasticidin.

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pUNO-mTollip

InvivoGen

Catalog Number: puno-mtollip
Description: pUNO-mTollip is a sequence-verified expression plasmid containing the murine Toll-interacting protein Toll-interacting protein (Tollip) was initially identified as an important constituent of the IL-1R signaling pathway. Recent data suggest that this protein is also involved in TLR2 and TLR4 signaling pathways. Tollip was reported to coimmunoprecipitate with TLR2 and TLR4 and overexpression of Tollip was shown to inhibit NF-kB activation in response to TLR2 and TLR4 signaling. Inhibition by Tollip is mediated through its ability to suppress the activity of IRAK. Therefore, Tollip may act as moderator of the inflammatory response following TLR activation.1. Burns K. et al.,2000. Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor. Nat Cell Biol, 2(6):346-512. Bulut Y. et al., 2001. Role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling. J Immunol, 167(2):987-943. Zhang, G. and S. Ghosh, 2002. Negative regulation of toll-like receptor-mediated signaling by Tollip. J Biol Chem, 277(9):7059-65 Plasmid is selectable in both mammalian cells and E. coli with Blasticidin.

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pUNO-mTRAF6

InvivoGen

Catalog Number: puno-mtraf6
Description: pUNO-mTRAF6 is a sequence-verified expression plasmid containing the murine TNF receptor-associated factor 6 open reading frame. Plasmid is selectable in both mammalian cells and E. coli with Blasticidin.

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