Mouse TLR Co-receptor Genes

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Catalog Number: puno-mcd14
Description: pUNO-mCD14 is a sequence-verified expression plasmid containing the murine Membrane-bound form CD14 is a glycosylphosphatidylinositol (GPI)-anchored membrane protein which acts as a bacterial pattern recognition receptor. CD14 is found on cells derived from the monocyte/macrophage lineage, as well as neutrophils and B lymphocytes. CD14 serves as a member of the heteromeric lipopolysaccharide (LPS) receptor complex that also contains TLR4 and MD2. CD14 binds LPS but is not capable of initiating a transmembrane activation signal since it does not contain a cytoplasmic domain. Upon LPS binding, CD14 physically associates with TLR4 which in turn transduces the signal. CD14 was also shown to interact with TLR2 in response to various microbial infections.1. Pugin J. et al., 1994. CD14 is a pattern recognition receptor. Immunity, 1(6):509-16.2. Da Silva Correia J. et al., 2001. Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. transfer from CD14 to TLR4 and MD-2. J Biol Chem, 276(24): 21129-35.3. Aderem A. & R.J. Ulevitch, 2000. Toll-like receptors in the induction of the innate immune response. Nature, 406(6797):782-7. Plasmid is selectable in both mammalian cells and E. coli with Blasticidin.

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Catalog Number: puno-mlbp
Description: pUNO-mLBP is a sequence-verified expression plasmid containing the murine Lipopolysaccharide Binding Protein Lipopolysaccharide (LPS)-binding protein (LBP) is a serum glycoprotein synthesized in the liver. LPB binds to a variety of LPS and to lipid A, the lipid moiety of LPS. LPS bound to LBP is a ligand for CD14 which in turn presents LPS to TLR4 by transferring LPS to MD2. LBP plays a dual role, both potentiating and decreasing cell responses to LPS. Low concentrations of LBP enhance cell stimulation, whereas high LBP concentrations inhibit cell responses to LPS. LBP attenuates signal responses by interfering with LPS transfer from CD14 to the TLR4/MD2 receptor complex. Plasmid is selectable in both mammalian cells and E. coli with Blasticidin.

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Catalog Number: puno-mmd1
Description: pUNO-mMD1 is a sequence-verified expression plasmid containing the murine Myeloid differentiation factor 1 MD-1 was identified by immunoprecipitation as a molecule that physically associates with RP105. Stable expression of MD-1 was shown to induce an increase in cell surface RP105 on a cell line that expresses RP105 alone, suggesting that MD-1 is important for efficient cell surface expression of RP105. Similarly to the TLR4/MD2 complex, the RP105/MD1 complex is involved in LPS response leading to LPS-induced B-cell proliferation, antibody production, and B7.2/CD86 up-regulation. MD-1 plays also a role in the regulation of allogeneic and xenogeneic skin graft survival. Plasmid is selectable in both mammalian cells and E. coli with Blasticidin.

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Catalog Number: puno-mmd2
Description: Murine MD2 ORF, provided in a pUNO plasmid. pUNO is a family of plasmids expressing genes involved in TLR signaling. pUNO plasmids are selectable in E. coli and mammalian cells with blasticidin.

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Catalog Number: puno-mrp105
Description: pUNO-mRP105 is a sequence-verified expression plasmid containing the murine RP105 RP105 (CD180), a TLR-related protein, was identified in B cells and acts as both an LPS sensor and a regulator of B cell proliferation1. B-cells lacking RP105 were shown to be severely impaired in LPS-induced proliferation and antibody production. Like TLR4, RP105 requires a MD2-related protein, MD1, for its surface expression. Furthermore, the expression of RP105 was reported to strongly increase during differentiation, suggesting that RP105 is also important in monocyte function2.1. Miyake K. et al., 2000. Innate recognition of lipopolysaccharide by Toll-like receptor 4/MD-2 and RP105/MD-1. J Endotoxin Res, 6(5):389-912. Zarember A. and PJ. Godowski, 2002. Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines. J Immunol, 168(2):554-61 Plasmid is selectable in both mammalian cells and E. coli with Blasticidin.

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