Mouse Native TLR Genes

pDUO-mMD1/RP105

InvivoGen

Catalog Number: pduo-mmd1rp105
Description: pDUO-MD1/RP105 is an expression vector designed to co-express MD1 and RP105 genes known to interact with each other : human MD1 (486 bp) and human RP105 (1983 bp) or murine MD1 (486 bp) and murine RP105 (1983 bp). The genes cloned into pDUO comprise the coding sequence (without introns) from the ATG to the Stop codon.

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pDUO-mMD2/TLR4

InvivoGen

Catalog Number: pduo-mmd2tlr4
Description: pDUO-MD2/TLR4 is an expression vector designed to co-express MD2 and TLR4 genes known to interact with each other : human MD2 (480 bp) and human TLR4A (2517 bp) or murine MD2 (480 bp) and murine TLR4 (2505 bp). The genes cloned into pDUO comprise the coding sequence (without introns) from the ATG to the Stop codon.

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pDUO-mTLR1/TLR2

InvivoGen

Catalog Number: pduo-mtlr1tlr2
Description: pDUO-TLR1/TLR2 is an expression vector designed to co-express TLR1 and TLR2 genes known to interact with each other : human TLR1 (2358 bp) and human TLR2 (2352 bp) or mouse TLR1 (2388 bp) and mouse TLR2 (2355 bp). The genes cloned into pDUO comprise the coding sequence (without introns) from the ATG to the Stop codon.

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pDUO-mTLR6/TLR2

InvivoGen

Catalog Number: pduo-mtlr6tlr2
Description: pDUO-TLR6/TLR2 is an expression vector designed to co-express TLR6 and TLR2 genes known to interact with each other : human TLR6 (2388 bp) and human TLR2 (2352 bp) or murine TLR6 (2418 bp) and murine TLR2 (2352 bp). The genes cloned into pDUO comprise the coding sequence (without introns) from the ATG to the Stop codon.

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pDUO2-hMD2/CD14

InvivoGen

Catalog Number: pduo2-hmd2cd14
Description: pDUO-hMD2/CD14 is an expression vector designed to co-express human MD2 and CD14 genes known to interact with each other: MD2 (480 bp) and CD14 (1125 bp). The genes cloned into pDUO comprise the coding sequence (without introns) from the ATG to the Stop codon.

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pDUO2-mMD2/CD14

InvivoGen

Catalog Number: pduo2-mmd2cd14
Description: pDUO-MD2/CD14 is an expression vector designed to co-express MD2 and CD14 genes known to interact with each other : human MD2 (480 bp) and human CD14 (1125 bp) or mouse MD2 (483 bp) and mouse CD14 (1101 bp). The genes cloned into pDUO comprise the coding sequence (without introns) from the ATG to the Stop codon.

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pUNO-mTLR1

InvivoGen

Catalog Number: puno-mtlr1
Description: pUNO-mTLR1 is a sequence-verified expression plasmid containing the murine Toll-Like Receptor 1 TLR1, the first member of the like-receptor family, was identified by the presence of a domain homology found in both Drosophila Toll and human interleukin-1 receptors. TLR1 is expressed at higher levels in the spleen and peripheral blood cells. No direct ligands have been identified so far for TLR1, and its function remains unclear. TLR1 seems to act as a coreceptor. TLR1 was shown to associate with TLR2 in response to triacylated lipopeptides, but not diacylated lipopeptides. These observations suggest that TLR1 is able to discriminate among lipoproteins by recognizing the lipid configuration. Plasmid is selectable in both mammalian cells and E. coli with Blasticidin.

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pUNO-mTLR11

InvivoGen

Catalog Number: puno-mtlr11
Description: Plasmid expressing murine TLR11.

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pUNO-mTLR13

InvivoGen

Catalog Number: puno-mtlr13
Description: pUNO-mTLR13 is a sequence-verified expression plasmid containing the murine Toll-Like Receptor 13 open reading frame. Plasmid is selectable in both mammalian cells and E. coli with Blasticidin.

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pUNO-mTLR2

InvivoGen

Catalog Number: puno-mtlr2
Description: pUNO-mTLR2 is a sequence-verified expression plasmid containing the murine Toll-Like Receptor 2 TLR2 is involved in the recognition of a wide array of microbial molecules. TLR2 recognizes peptidoglycan, lipoteichoic acid and lipoprotein from gram-positive bacteria, lipoarabinomannan from mycobacteria, and zymosan from yeast cell wall. Moreover, TLR2 participates in the recognition of some types of LPS. TLR2 is known to heterodimerize with other TLRs, a property believed to extend the range of microbial molecules that TLR2 can recognize. TLR2 cooperates with TLR6 in response to diacylated mycoplasmal lipopeptide, and associates with TLR1 to recognize triacylated lipopetides. Furthermore, pathogen recognition by TLR2 is strongly enhanced by CD14. Plasmid is selectable in both mammalian cells and E. coli with Blasticidin.

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pUNO-mTLR3

InvivoGen

Catalog Number: puno-mtlr3
Description: pUNO-mTLR3 is a sequence-verified expression plasmid containing the murine Toll-like Receptor 3 TLR3 recognizes double-stranded RNA (dsRNA), a molecular pattern associated with viral infection. Stimulation with polyinosine-polycytidylic acid (poly(I:C)), a synthetic analog of dsRNA, was shown to induce hyporesponsiveness in TLR3-deficient mice and marked responsiveness only in 293 cells expressing TLR3, suggesting a specific recognition to poly(I:C) by TLR3. Furthermore, TLR3 signaling is not elicited by either single-stranded RNA (ssRNA) or dsDNA. TLR3 activation induces cytokine production through a signaling pathway dependent on MyD88. Moreover, poly(I:C) can induce activation of NF-?B and mitogen-activated protein kinases independently of MyD88, and cause dendritic cells to mature. Plasmid is selectable in both mammalian cells and E. coli with Blasticidin.

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pUNO-mTLR4

InvivoGen

Catalog Number: puno-mtlr4
Description: pUNO-mTLR4 is a sequence-verified expression plasmid containing the murine Toll-Like Receptor 4 TLR4, the first human TLR identified, is the receptor for Gram-negative lipopolysaccharide (LPS). The TLR4 gene was shown to be mutated in C3H/HeJ and C57BL/10ScCr mice, both of which are low responders to lipopolysaccharide (LPS). However, TLR4 alone is not sufficient to confer LPS responsiveness. TLR4 requires MD-2, a secreted molecule, to functionally interact with LPS. Furthermore, a third protein, called CD14, was shown to participate in LPS signaling, leading to NF-?B translocation. This signaling is mediated through the adapter protein MyD88 but also through a MyD88-independent pathway that involves the (TIR) domain-containing adapter protein (TIRAP). Plasmid is selectable in both mammalian cells and E. coli with Blasticidin.

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pUNO-mTLR5

InvivoGen

Catalog Number: puno-mtlr5
Description: pUNO-mTLR5 is a sequence-verified expression plasmid containing the murine Toll-Like Receptor 5 TLR5 is the Toll-like molecule that recognizes flagellin from both Gram-positive and Gram-negative bacteria. TLR5 was identified by the presence of the TIR domain and is expressed in spleen, peripheral blood leukocytes and epithelial cells. Activation of the receptor stimulates the production of proinflammatory cytokines, such as TNF-a, through signaling via the adaptor protein MyD88 and the serine kinase IRAK [1, 2]. TLR5 can generate a proinflammatory signal as a homodimer suggesting that it might be the only TLR required for flagellin recognition. Plasmid is selectable in both mammalian cells and E. coli with Blasticidin.

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pUNO-mTLR6

InvivoGen

Catalog Number: puno-mtlr6
Description: pUNO-mTLR6 is a sequence-verified expression plasmid containing the murine Toll-Like Receptor 6 TLR6 is expressed in spleen and BPL and, similarly to TLR1, acts as a co-receptor. Studies with dominant negative receptors have shown that TLR6 cooperates with TLR2 to recognize peptidoglycan and the yeast cell wall particle, zymosan. Furthermore, TLR6- and TLR2-deficient mice were reported to be hyporesponsive to mycoplasma macrophage-activating lipopeptide-2 kD (MALP-2), a diacylated lipoprotein, suggesting that TLR2 and TLR6 coordinate the response to this ligand. By contrast, TLR2 is able to recognize bacterial lipoproteins triacylated at the N-terminus cysteine residue. Thus TLR6 appears to discriminate between the N-terminal lipoylated structures of MALP-2 and lipopeptides derived from other bacteria. Plasmid is selectable in both mammalian cells and E. coli with Blasticidin.

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pUNO-mTLR7

InvivoGen

Catalog Number: puno-mtlr7
Description: pUNO-mTLR7 is a sequence-verified expression plasmid containing the murine Toll-Like Receptor 7 TLR7 is abundantly expressed in lung, placenta, spleen and BPL. TLR7 is phylogenetically close to TLR8 and TLR9 and has a higher molecular weight when compared with hTLR1-6, largely as a result of a longer ectodomain. The natural ligand for TLR7 has not yet been identified. However, studies with TLR7-deficient mice have shown that TLR7 recognizes imidazoquinoline compounds, such as R848, a small synthetic antiviral molecule. Imidazoquinoline signaling involves the MyD88-dependent signaling cascade and induces the production of IFN-a, TNF-a and IL-12. Plasmid is selectable in both mammalian cells and E. coli with Blasticidin.

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pUNO-mTLR8

InvivoGen

Catalog Number: puno-mtlr8
Description: pUNO-mTLR8 is a sequence-verified expression plasmid containing the murine Toll-Like Receptor 8 TLR8 was identified together with TLR7 and TLR9 and is expressed more abundantly in PBL and lung. The natural ligand for TLR8 is still unknown. Recently, human TLR8 and TLR7 were reported to independently confer responsiveness to R848, an imidazoquinoline compound with antiviral activity. Upon R848 stimulation, HEK293 cells transfected with human TLR8 induced NF-?B activation in a dose-dependent manner. In contrast, HEK293 cells expressing murine TLR8 were hyporesponsive to R848 suggesting that TLR8 is nonfunctional in mice. Plasmid is selectable in both mammalian cells and E. coli with Blasticidin.

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pUNO-mTLR9

InvivoGen

Catalog Number: puno-mtlr9
Description: Murine TLR9 ORF, provided in a pUNO plasmid. pUNO is a family of plasmids expressing genes involved in TLR signaling. pUNO plasmids are selectable in E. coli and mammalian cells with blasticidin.

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