Human TLR Signaling Genes

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pUNO-hIKKE

InvivoGen

Catalog Number: puno-hikke
Description: pUNO-hIKKE is a sequence-verified expression plasmid containing the human Inhibitor of Kappa light polypeptide gene enhancer in B-cells, Kinase Epsilon open reading frame. Plasmid is selectable in both mammalian cells and E. coli with Blasticidin.

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pUNO-hIRAK1

InvivoGen

Catalog Number: puno-hirak1
Description: pUNO-hIRAK1 is a sequence-verified expression plasmid containing the human IL-1R associated kinase 1 Interleukin-1 receptor-associated kinases (IRAKs) are serine/threonine kinases that act as signal transduction mediators for the TLRs. The IRAK family consists of two active kinases, IRAK-1 and IRAK-4, and two inactive kinases, IRAK-2 and IRAK-M. Upon stimulation, the adaptor MyD88 recruits IRAK-1, IRAK-2 and IRAK-4 to the receptor. IRAK-4 then phosphorylates IRAK-1 which dissociates from the receptor and interacts directly with TRAF-6 to relay the signal. Subsequently, IRAK-1 undergoes autophosphorylation followed by degradation. IRAK-4 is an essential component of the IL-1, IL-18 and TLR signaling cascade[2-4].1. Janssens S. & Beyaert R., 2003. Functional diversity and regulation of different interleukin-1 receptor-associated kinase (IRAK) family members. Mol Cell. 11(2):293-302.2. Li S. et al., 2002. IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase.Proc Natl Acad Sci U S A. 99(8):5567-72.3. Lye E. et al., 2004. The role of interleukin 1 receptor-associated kinase-4 (IRAK-4) kinase activity in IRAK-4-mediated signaling. J Biol Chem. 279(39):40653-8.4. Suzuki N et al., 2003. IL-1 receptor-associated kinase 4 is essential for IL-18-mediated NK and Th1 cell responses. J Immunol. 170(8):4031-5. Plasmid is selectable in both mammalian cells and E. coli with Blasticidin.

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pUNO-hIRAK4

InvivoGen

Catalog Number: puno-hirak4
Description: pUNO-hIRAK4 is a sequence-verified expression plasmid containing the human IL-1R associated kinase 4 Interleukin-1 receptor-associated kinases (IRAKs) are serine/threonine kinases that act as signal transduction mediators for the TLRs. The IRAK family consists of two active kinases, IRAK-1 and IRAK-4, and two inactive kinases, IRAK-2 and IRAK-M. Upon stimulation, the adaptor MyD88 recruits IRAK-1, IRAK-2 and IRAK-4 to the receptor. IRAK-4 then phosphorylates IRAK-1 which dissociates from the receptor and interacts directly with TRAF-6 to relay the signal. Subsequently, IRAK-1 undergoes autophosphorylation followed by degradation. IRAK-4 is an essential component of the IL-1, IL-18 and TLR signaling cascade[2-4].1. Janssens S. & Beyaert R., 2003. Functional diversity and regulation of different interleukin-1 receptor-associated kinase (IRAK) family members. Mol Cell. 11(2):293-302.2. Li S. et al., 2002. IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase.Proc Natl Acad Sci U S A. 99(8):5567-72.3. Lye E. et al., 2004. The role of interleukin 1 receptor-associated kinase-4 (IRAK-4) kinase activity in IRAK-4-mediated signaling. J Biol Chem. 279(39):40653-8.4. Suzuki N et al., 2003. IL-1 receptor-associated kinase 4 is essential for IL-18-mediated NK and Th1 cell responses. J Immunol. 170(8):4031-5. Plasmid is selectable in both mammalian cells and E. coli with Blasticidin.

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pUNO-hIRAKM

InvivoGen

Catalog Number: puno-hirakm
Description: pUNO-hIRAKM is a sequence-verified expression plasmid containing the human IL-1R associated kinase M Interleukin-1 receptor-associated kinase (IRAK)-M is an inactive kinase found mainly in cells of the monocytic lineage, whereas other IRAKs are ubiquitous. IRAK-M negatively regulates TLR signaling. TLR stimulation induces IRAK-M which in turn down-regulates TLR signaling by preventing the dissociation of IRAK-1 and IRAK-4 from MyD88 and the formation of IRAK-1/TRAF6 complexes. IRAK-M-deficient cells exhibit increased cytokine production upon LPS stimulation and reduced endotoxin tolerance. IRAK-M is also involved in peptidoglycan-induced tolerance.1. Wesche H. et al., 1999. IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family. J Biol Chem, 274(27):19403-10.2. Kobayashi K. et al., 2002. IRAK-M is a negative regulator of Toll-like receptor signaling. Cell, 110(2): 191-202.3. Nakayama K. et al., 2004. Involvement of IRAK-M in peptidoglycan-induced tolerance in macrophages. J Biol Chem. 279(8):6629-34. Plasmid is selectable in both mammalian cells and E. coli with Blasticidin.

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pUNO-hIRF3

InvivoGen

Catalog Number: puno-hirf3
Description: pUNO-hIRF3 is a sequence-verified expression plasmid containing the human Interferon Regulatory Factor 3 open reading frame. Plasmid is selectable in both mammalian cells and E. coli with Blasticidin.

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pUNO-hIRF5a

InvivoGen

Catalog Number: puno-hirf5a
Description: pUNO-hIRF5a is a sequence-verified expression plasmid containing the human Interferon Regulatory Factor 5 open reading frame. Plasmid is selectable in both mammalian cells and E. coli with Blasticidin.

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pUNO-hIRF5b

InvivoGen

Catalog Number: puno-hirf5b
Description: Plasmid expressing human IRF5b.

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pUNO-hIRF7

InvivoGen

Catalog Number: puno-hirf7
Description: Human IRF7 ORF, provided in a pUNO plasmid. pUNO is a family of plasmids expressing genes involved in TLR signaling. pUNO plasmids are selectable in E. coli and mammalian cells with blasticidin.

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pUNO-hLBP

InvivoGen

Catalog Number: puno-hlbp
Description: pUNO-hLBP is a sequence-verified expression plasmid containing the human Lipopolysaccharide Binding Protein Lipopolysaccharide (LPS)-binding protein (LBP) is a serum glycoprotein synthesized in the liver. LPB binds to a variety of LPS and to lipid A, the lipid moiety of LPS. LPS bound to LBP is a ligand for CD14 which in turn presents LPS to TLR4 by transferring LPS to MD2. LBP plays a dual role, both potentiating and decreasing cell responses to LPS. Low concentrations of LBP enhance cell stimulation, whereas high LBP concentrations inhibit cell responses to LPS. LBP attenuates signal responses by interfering with LPS transfer from CD14 to the TLR4/MD2 receptor complex. Plasmid is selectable in both mammalian cells and E. coli with Blasticidin.

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pUNO-hMAP3K7a

InvivoGen

Catalog Number: puno-hmap3k7a
Description: Plasmid expressing human MAP3K7a.

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pUNO-hMAP3K7b

InvivoGen

Catalog Number: puno-hmap3k7b
Description: pUNO-hMAP3K7b is a sequence-verified expression plasmid containing the human Mitogen-activated protein kinase kinase kinase 7TGF-beta activated kinase 1Transcript variant 2 (long) open reading frame. Plasmid is selectable in both mammalian cells and E. coli with Blasticidin.

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pUNO-hMAP3K7d

InvivoGen

Catalog Number: puno-hmap3k7d
Description: Plasmid expressing human MAP3K7d.

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pUNO-hNEMO

InvivoGen

Catalog Number: puno-hnemo
Description: pUNO-hNEMO is a sequence-verified expression plasmid containing the human NF-kappaB Essential Modulator.Inhibitor of Kappa light polypeptide gene enhancer in B-cells, Kinase Gamma open reading frame. Plasmid is selectable in both mammalian cells and E. coli with Blasticidin.

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pUNO-hPELI-1

InvivoGen

Catalog Number: puno-hpeli1
Description: Human PELI-1 ORF, provided in a pUNO plasmid. pUNO is a family of plasmids expressing genes involved in TLR signaling. pUNO plasmids are selectable in E. coli and mammalian cells with blasticidin.

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pUNO-hPELI-2

InvivoGen

Catalog Number: puno-hpeli2
Description: Human PELI-2 ORF, provided in a pUNO plasmid. pUNO is a family of plasmids expressing genes involved in TLR signaling. pUNO plasmids are selectable in E. coli and mammalian cells with blasticidin.

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pUNO-hPELI-3a

InvivoGen

Catalog Number: puno-hpeli3a
Description: Human PELI-3a ORF, provided in a pUNO plasmid. pUNO is a family of plasmids expressing genes involved in TLR signaling. pUNO plasmids are selectable in E. coli and mammalian cells with blasticidin.

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pUNO-hPELI-3b

InvivoGen

Catalog Number: puno-hpeli3b
Description: Plasmid expressing human PELI-3b.

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pUNO-hPKR

InvivoGen

Catalog Number: puno-hpkr
Description: pUNO-hPKR is a sequence-verified expression plasmid containing the human Protein Kinase, Interferon-inducible double stranded RNA dependent Protein kinase RNA-regulated (PKR), an ubiquitous serine/threonine kinase that is induced by interferons, is a critical signal transducer implicated in different stress-induced signaling pathways including dsRNA-induced TLR3 signaling and LPS-induced TLR4 signaling[2,3]. Upon stress stimulation, PKR is activated by autophosphorylation and subsequently phosphorylates the alpha-subunit of eukaryotic initiation factor 2 (eIF-2a) thereby inducing apoptosis. PKR mediates the activation of important transcription factors, such as NF-kB, and MAP kinases, such as p382, by interacting with the TAK1 complex.1. Jiang Z. et al., 2003. Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR. J Biol Chem. 278(19):16713-9. 2. Goh KC. et al., 2000. The protein kinase PKR is required for p38 MAPK activation and the innate immune response to bacterial endotoxin. EMBO J. 19(16):4292-7.3. Hsu LC. et al., 2004. The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4. Nature. 2004 Mar 18;428(6980):341-5. Plasmid is selectable in both mammalian cells and E. coli with Blasticidin.

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pUNO-hRIPK1

InvivoGen

Catalog Number: puno-hripk1
Description: pUNO-hRIPK1 is a sequence-verified expression plasmid containing the human Receptor-interacting serine-threonine kinase 1 Receptor-interacting protein (RIP1), a serine/threonine kinase, mediates the activation of NF-kB in response to TNF. RIP1 belongs to a family of related kinases that includes RIP2 and RIP3 that share significant homology in their N termini but possess distinct C termini. RIP1 contains a death domain (DD) and interacts with proteins containing DD such as TNFR1, Fas, TRAIL and FADD. Recently, RIP1 was shown to be an essential mediator of TLR3-induced NF-kB activation. TLR3 signals through TRIF which recruits RIP1 which in turn associates with IKK leading to the activation of NF-kB.1. Kelliher MA. et al., 1998. The death domain kinase RIP mediates the TNF-induced NF-kappaB signal. Immunity. 8(3):297-303.2. Sun X. et al., 1999. RIP3, a novel apoptosis-inducing kinase. J Biol Chem. 274(24):16871-5.3. Lin Y. et al., 2000. The death domain kinase RIP is essential for TRAIL (Apo2L)-induced activation of IkappaB kinase and c-Jun N-terminal kinase.Mol Cell Biol. 20(18):6638-45.4. Meylan E. et al., 2004. RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation. Nat Immunol. 5(5):503-7. Plasmid is selectable in both mammalian cells and E. coli with Blasticidin.

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pUNO-hRIPK2

InvivoGen

Catalog Number: puno-hrick
Description: pUNO-hRIPK2 is a sequence-verified expression plasmid containing the human Receptor-interacting serine-threonine kinase 2Caspase recruitment domain-containing protein 3 Other aliases: RIP2, CARDIAKReceptor-interacting protein 2 (RIP2), also known as RICK, Rip2, CARDIAK and CARD3, is a serine/threonine kinase characterized by a C-terminal caspase activation and recruitment domain (CARD). Beside caspase activation, RIP2 is implicated in NF-kB activation. It acts as a signal transducer for pattern-recognition receptors, including TLRs and NODs[1-4]. RIP2 is recruited to certain TLR-signaling complexes after ligand stimulation promoting the activation of NF-kB and the production of proinflammatory cytokines. Furthermore, RIP2 is required for optimal TCR signalling and T-cell differentiation. Thus RIP2 is an essential mediator for both the innate and adaptive immune responses.1. Kobayashi K. et al., 2002. RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature 416(6877):194-9.2. Chin AI. et al., 2002. Involvement of receptor-interacting protein 2 in innate and adaptive immune responses. Nature 416(6877):190-4.3. Pauleau AL. & Murray PJ., 2003. Role of nod2 in the response of macrophages to toll-like receptor agonists. Mol Cell Biol. 23(21):7531-9.4. Girardin SE. et al., 2001. CARD4/Nod1 mediates NF-kappaB and JNK activation by invasive Shigella flexneri.EMBO Rep.2(8):736-42. Plasmid is selectable in both mammalian cells and E. coli with Blasticidin.

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pUNO-hRIPK3

InvivoGen

Catalog Number: puno-hripk3
Description: Human RIPK3 ORF, provided in a pUNO plasmid. pUNO is a family of plasmids expressing genes involved in TLR signaling. pUNO plasmids are selectable in E. coli and mammalian cells with blasticidin.

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pUNO-hTBK1

InvivoGen

Catalog Number: puno-htbk1
Description: pUNO-hTBK1 is a sequence-verified expression plasmid containing the human TANK-Binding Kinase 1 open reading frame. Plasmid is selectable in both mammalian cells and E. coli with Blasticidin.

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pUNO-hTNFAIP3

InvivoGen

Catalog Number: puno-htnfaip3
Description: pUNO-hTNFAIP3 is a sequence-verified expression plasmid containing the human Tumor necrosis factor alpha-induced protein 3 The zinc finger protein A20, also called tumor necrosis factor, alpha-induced protein 3 (TNFAIP3), is a TNF- and IL-1-inducible protein that negatively regulates NF-kB-dependent gene expression. A20 is encoded by an immediate early response gene whose expression is induced by different inflammatory stimuli. A20 inhibits NF-kB activation induced by the TLR2 ligand PGN or the TLR4 ligand LPS[1,2], as well as IFN-beta transcription triggered by the TLR3 ligand ds RNA, the inhibition taking place at the level of TRAF6. Thus A20 acts as a negative regulator of TLR-mediated inflammatory responses, thereby protecting the host against harmful overresponses to pathogens.1. OReilly SM. & Moynagh PN., 2003. Regulation of Toll-like receptor 4 signalling by A20 zinc finger protein. Biochem Biophys Res Commun. 303(2):586-93.2. Gon Y. et al., 2004. A20 inhibits toll-like receptor 2- and 4-mediated interleukin-8 synthesis in airway epithelial cells. Am J Respir Cell Mol Biol. 31(3):330-6.3. Wang YY, A20 is a potent inhibitor of TLR3- and Sendai virus-induced activation of NF-kappaB and ISRE and IFN-beta promoter. FEBS Lett. 2004 Oct 8;576(1-2):86-90.4. Heyninck K. & Beyaert R. 1999. The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-kappaB activation at the level of TRAF6. FEBS Lett. 442(2-3):147-50. Plasmid is selectable in both mammalian cells and E. coli with Blasticidin.

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pUNO-hTollip

InvivoGen

Catalog Number: puno-htollip
Description: pUNO-hTollip is a sequence-verified expression plasmid containing the human Toll-interacting protein Toll-interacting protein (Tollip) was initially identified as an important constituent of the IL-1R signaling pathway. Recent data suggest that this protein is also involved in TLR2 and TLR4 signaling pathways. Tollip was reported to coimmunoprecipitate with TLR2 and TLR4 and overexpression of Tollip was shown to inhibit NF-kB activation in response to TLR2 and TLR4 signaling. Inhibition by Tollip is mediated through its ability to suppress the activity of IRAK. Therefore, Tollip may act as moderator of the inflammatory response following TLR activation.1. Burns K. et al.,2000. Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor. Nat Cell Biol, 2(6):346-512. Bulut Y. et al., 2001. Role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling. J Immunol, 167(2):987-943. Zhang, G. and S. Ghosh, 2002. Negative regulation of toll-like receptor-mediated signaling by Tollip. J Biol Chem, 277(9):7059-65 Plasmid is selectable in both mammalian cells and E. coli with Blasticidin.

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pUNO-hTRAF6

InvivoGen

Catalog Number: puno-htraf6
Description: pUNO-hTRAF6 is a sequence-verified expression plasmid containing the human TNF receptor-associated factor 6 open reading frame. Plasmid is selectable in both mammalian cells and E. coli with Blasticidin.

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pUNO-sahIRF3

InvivoGen

Catalog Number: puno-sahirf3
Description: pUNO-hsaIRF3 is a sequence-verified expression plasmid containing the human Super activated Interferon Regulatory Factor 3 open reading frame. saIRF3 was generated by creating a single point mutation of Ser396 to Asp and presents a >>10-fold enhanced transactivating potential over the wild-type IRF3 for the IFNA and IFNB promoters. Plasmid is selectable in both mammalian cells and E. coli with Blasticidin.

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pUNO-sahIRF7delta

InvivoGen

Catalog Number: puno-sahirf7d
Description: pUNO-hsaIRF7? is a sequence-verified expression plasmid containing the human Super activated Interferon Regulatory Factor 7 open reading frame. Super activated IRF7 (saIRF7?) was constructed by deleting the auto-inhibitory domain (D238-410) producing a protein extremely more active than full-length IRF7, even in the absence of viral infection. Plasmid is selectable in both mammalian cells and E. coli with Blasticidin.

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