Using synthetic biology methods, Scarab Genomics made a series of planned, precise deletions to the E. coli K-12 genome, reducing the genome by about 15%. The multiple deletion series (MDS™) strains eliminate non-essential genes, cryptic virulence genes, and sequences for recombinogenic and mobile insertion sequence DNA, while preserving robust growth in rich and minimal media. Genome reduction results in superior genomic and plasmid stability and increased cloning success with “unclonable” genes. Clean Genome E. coli are safer and have reduced background to significantly improve molecular biology applications and biotherapeutic production.
Clean Genome® E. coli MDS™ Competent Cells
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