Ghrelin and Obestatin Peptides are GO®

Ghrelin and Obestatin Peptides are GO®

AnaSpec, EGT Group, a leading provider of integrated proteomic and genomic solutions, offers a wide range of ghrelin and obestatin GO® (catalog) peptides for research use.

In 1999, Kojima and his group (1) reported the discovery of a growth hormone secretagogue that is involved in the release of growth hormone from the anterior pituitary through activation of the growth hormone secretagogue receptor (GHS-R), which they termed Ghrelin (ghre from a Proto-Indo-European root meaning to grow). Ghrelin, a 28-amino-acid peptide hormone produced by the stomach of mammals, is a peptide with an n-octanoyl modification at Ser3 (n-octanoylation is essential for its activity). It stimulates appetite and food intake and decreases fat utilization. The secretion of ghrelin is augmented under conditions of both gastric emptying and filling, and its release stimulated by intestinal hormones (1-5).

In 2005, Hsueh’s group (6) found a peptide fragment from the same ghrelin gene that has opposite effects from those of Ghrelin. They named this peptide Obestatin (obedere from Latin, meaning to devour, and statin denoting suppression). Obestatin binds to the orphan G protein-coupled receptor GPR39 and suppresses food intake, inhibits jejunal contraction and decreases body weight gain (6).

Table 1. Human ghrelin peptides.

Product

Size

Catalog #

Ghrelin, human
GS-S(n-octanoyl)-FLSPEHQRVQQRKESKKPPAKLQPR

1 mg

5 mg

24157

24158

[Des-octanoyl]-Ghrelin, human
GSSFLSPEHQRVQQRKESKKPPAKLQPR

1 mg

61177

Ghrelin, human, FAM-labeled
FAM-GS-S(n-octanoyl)- FLSPEHQRVQQRKESKKPPAKLQPR

0.1 mg

0.5 mg

29396

29397

Ghrelin, human, TAMRA-labeled
TAMRA-GS-S(n-octanoyl)-FLSPEHQRVQQRKESKKPPAKLQPR

0.1 mg

0.5 mg

29387

29388

Biotin-Ghrelin, human
Biotin-GS-S(n-octanoyl)-FLSPEHQRVQQRKESKKPPAKLQPR

1 mg

5 mg

29391

29392

Table 2. Ghrelin peptides from bovine, rat and related peptides.

Product

Size

Catalog #

Ghrelin (1-18)
GS-S(n-octanoyl)-FLSPEHQRVQQRKES

1 mg

62358

Ghrelin, bovine
GS-S(n-octanoylated)-FLSPEHQKLQRKEAKKPSGRLKPR

1 mg

60870

Biotin-Ghrelin, bovine
Biotin-GS-S(n-octanoylated)-FLSPEHQKLQRKEAKKPSGRLKPR

1 mg

61714

Ghrelin, rat
GS-S(n-octanoyl)-FLSPEHQKAQQRKESKKPPAKLQPR

1 mg

5 mg

24159

24160

[Des-octanoyl]-Ghrelin, rat
GSSFLSPEHQKAQQRKESKKPPAKLQPR

1 mg

60981

[Ala¹, D-Trp^2,4, Leu⁶]-Ghrelin Receptor Agonist
AwFwLL

1 mg

62931

[D-Trp1,3, Leu5]-Ghrelin Core-Ligand
wFwLL

1 mg

62930

C-terminal Proghrelin Isoform Peptide, mouse
RRQLTSNHGQA

1 mg

61905

Table 3. Obestatin peptides listing.

Product

Size

Catalog #

Obestatin (11 - 23), human
LSGVQYQQHSQAL

1 mg

62041

Obestatin (11 - 23), rat, mouse
LSGAQYQQHGRAL

1 mg

62040

Obestatin, human
FNAPFDVGIKLSGVQYQQHSQAL - NH2

1 mg

5 mg

61434-1

61434-5

Obestatin, rat, mouse
FNAPFDVGIKLSGAQYQQHGRAL - NH2

1 mg

5 mg

61435-1

61435-5

References:

1. Kojima, M. et al. Nature 402, 656 (1999).
2. Kleinz, MJ. et al. Cardiovasc Res. 69, 227 (2006).
3. Murakami, N. et al. J. Endocrinol. 174, 283 (2002).
4. Nishi, Y. et al. Endocrinol. 146, 2709 (2005).
5. Cowley, MA. et al. Neuron 37, 649 (2003).
6. Zhang, JV. et al. Science 310, 996 (2005).