Fig 1: Chronic kidney disease (CKD) model mice exhibit elevated serum corin levels and cardiac corin expression. A, Serum corin levels before, 4 weeks after, and 8 weeks after 5/6 nephrectomy or sham surgery. B, Relative mRNA expression of the corin gene. C, Western blot for corin protein quantitation in cardiac tissues. D, Corin protein expression levels in sham control mouse and CKD mouse heart tissues 8 weeks postsurgery. E and F, Immunohistochemistry (IHC) staining for corin shows enhanced cytoplasmic corin labeling in CKD mouse heart tissues 8 weeks postsurgery. G and H, Proatrial natriuretic peptide conversion assay and associated calculated conversion ratio data (8 weeks postsurgery). *P<0.05, **P<0.001 between groups. ANP indicates atrial natriuretic peptide.