Fig 2: Impact of Lbp gene knockdown in Hepa1-6 cells(A–G) Effects of Lbp gene knockdown in vehicle (BSA5%, 24 h)- and palmitate-treated (200 µM, 24 h) Hepa1-6 cells on Lbp (A), Srebf1 (B), and Scd1 (C) gene expression, ACC protein (D), ACC and AMPK activity (E and F), NADPH production-, antioxidant response-, and ER stress (Syvn1, Atf6 and Hspa5)-related gene expression (G–I), and cellular viability and activity (MTT assay) (J). *p < 0.05, **p < 0.01, and ***p < 0.001 compared with shC; †p < 0.05, ††p < 0.01, and †††p < 0.001 compared with BSA.