- Human Regulatory T Cell Staining Kit Kit
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- 88-8999-40
- Kit
- Intracellular Staining Followed by Flow Cytometric Analysis
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- Flow Cytometry staining
- Human
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- Human Regulatory T Cell Staining Kit Kit
- Forkhead Box P3, Scurfin, JM2, Treg, Foxp3 PCH101 PE; CD4 FITC: CD25 APC
- RUO
Product Description
Regulatory T cells/Tregs (also known as suppressor T cells) are a specialized subpopulation of T cells that act to suppress immune responses thereby maintaining homeostasis and self tolerance. Intense investigation has tried to determine exclusive protein markers for Tregs. This has been complicated by the identification of four regulatory T cells subsets; natural, anergic, Tr1 and CD8+CD28- suppressor T cells. There are still no cell surface molecules that uniquely distinguish functional regulatory cells from conventional T cells. It has been proposed that the "natural" regulatory T cells originally recognized by their constitutive expression of CD4 and CD25 are further defined by expression of the transcription factor Foxp3. Additionally Foxp3 has also been characterized in CD8+CD28- suppressor T cells.<br /><br />The Complete Regulatory T Cell Staining Kit contains everything needed to stain the natural Tregs including CD4, CD25 and Foxp3. <br /><br />This kit has been optimized for staining normal hPBMCs.<br /><br />Not included:<br />Isotype control for anti-CD4 and anti-CD25 (cocktail of FITC & APC mouse IgG1, cat. 22-1714)