Description
Product Characteristics:
VAPB contains 1 MSP domain and it may play a role in vesicle trafficking. Defects in VAPB are a cause of proximal adult autosomal dominant spinal muscular atrophy [MIM:182980], also called late onset spinal muscular atrophy Finkel type. Spinal muscular atrophies are neurodegenerative disorders characterized by degeneration of lower motor neurons, leading to progressive paralysis muscular atrophy. This form is a late adult onset form of the disease (after age 20 years). The patients show a benign course, most of them remaining ambulatory 10 to 40 years after clinical onset.
Subcellular location: Cytoplasm
Synonyms: ALS 8, ALS8, D2Abb2e, UNQ484/PRO983, Vamp 33b, VAMP associated 33 kDa protein, VAMP associated protein B and C, VAMP associated protein B, VAMP associated protein B/C, VAMP associated protein C, VAMP B, VAMP B VAMP C, VAMP B/VAMP C, VAMP C, VAMP vesicle associated membrane protein associated protein B and C, Vamp33b, VAMPB, VAMPB/VAMPC, VAMPC, VAP 33b, VAP B, VAP B/VAP C, VAP C, VAP33b, VAPB/VAPC, VAPC antibody Vesicle associated membrane protein associated protein B and C, Vesicle associated membrane protein associated protein B/C, VAPB_HUMAN.
Target Information: The protein encoded by this gene is a type IV membrane protein found in plasma and intracellular vesicle membranes. The encoded protein is found as a homodimer and as a heterodimer with VAPA. This protein also can interact with VAMP1 and VAMP2 and may be involved in vesicle trafficking. [provided by RefSeq, Jul 2008]