Description
Product Characteristics:
Receptor for brain injury-derived neurotrophic peptide (BINP), a synthetic 13-mer peptide.
Subcellular location: Cell membrane
Synonyms: BBP, RIS1, p40BBP, Transmembrane protein 158, 40 kDa BINP-binding protein, Ras-induced senescence protein 1, TMEM158, HBBP
Target Information: Constitutive activation of the Ras pathway triggers an irreversible proliferation arrest reminiscent of replicative senescence. Transcription of this gene is upregulated in response to activation of the Ras pathway, but not under other conditions that induce senescence. The encoded protein is similar to a rat cell surface receptor proposed to function in a neuronal survival pathway. [provided by RefSeq, Jul 2008]