Description
Product Characteristics:
LRFN2 is a 789 amino acid single-pass type I membrane protein belonging to the LRFN family. Encoded by a gene that maps to human chromosome 6p21.2, LRFN2 is moderately expressed in brain, spleen and testis. LRFN2 contains one fibronectin type-III domain, one Ig-like (immunoglobulin-like) domain and six LRR (leucine-rich) repeats. LRFN2 promotes neurite outgrowth in hippocampal neurons, enhances cell surface expression of two NMDA receptor subunits, NMDA1 and NMDA?1, and may play a role in redistributing PSD-95 to cell periphery. LRFN2 forms heteromeric complexes with LRFN1, LRFN3, LRFN4 and LRFN5, and is capable of forming homomeric complexes, but not across cell junctions.
Subcellular location: Cell membrane
Synonyms: leucine rich repeat and fibronectin type III domain containing 2, RP11-535K1.2, fibronectin type III, immunoglobulin and leucine rich repeat domains 2 antibody FIGLER2, Leucine-rich repeat and fibronectin type-III domain-containing protein 2, LRFN2, LRFN2_HUMAN, SALM1, Synaptic adhesion-like molecule 1.
Target Information: Promotes neurite outgrowth in hippocampal neurons. Enhances the cell surface expression of 2 NMDA receptor subunits GRIN1 and GRIN2A (By similarity). May play a role in redistributing DLG4 to the cell periphery