Description
Product Characteristics:
Clathrin-coated pits and vesicles are assembled for receptor-mediated endocytosis through interaction with Clathrin associated protein complexes. Vesicle transport is mediated from the trans-Golgi network by the adapter complex AP-1 and from the plasma membrane by the AP-2 complex. The AP-1 and AP-2 adapter protein complexes consist of Clathrin binding Adaptin proteins (g and b1 for AP-1, a and b2 for AP-2) and two smaller subunits known as AP50 and AP17. The a and b Adaptin chains have a similar two-domain organization with C-terminal domains that vary in both sequence and length. a-Adaptin splice variants A and C display variable relative expression levels and differential distribution in different tissues. AP-3 (also designated AP180 or F1-20) is a synapse-specific Clathrin assembly protein. The protein CALM (Clathrin assembly protein lymphoid myeloid leukemia) is highly homologous to AP180 and may also be involved in Clathrin assembly.
Subcellular location: Cytoplasm, Cell membrane
Synonyms: AP 180, AP3, Assembly Protein 180 kDa, Assembly Protein AP180, CALM, Clathrin coat assembly protein, Clathrin coat assembly protein AP180, Clathrin coat associated protein AP180, DKFZp781O051, F120, KIAA0656, NP185, pp155, SNAP 91, SNAP91, 91 kDa synaptosomal associated protein, Synaptosomal associated protein 91 kD homolog, Synaptosomal associated protein 91 kDa homolog, AP180_HUMAN.
Target Information: plays a role in clathrin-dependent assembly of synaptic vesicles at the presynaptic terminal