Description
Product Characteristics:
Involved in apoptosis and cell survival. Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53.
Subcellular location: Cytoplasm
Synonyms: ICERE-1, Non-syndromic hearing impairment protein 5, Inversely correlated with estrogen receptor expression 1, DFNA5, ICERE1
Target Information: Hearing impairment is a heterogeneous condition with over 40 loci described. The protein encoded by this gene is expressed in fetal cochlea, however, its function is not known. Nonsyndromic hearing impairment is associated with a mutation in this gene. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]