Description
Product Characteristics:
Activates the metallothionein I promoter. Binds to the metal responsive element (MRE).
Subcellular location: Nucleus
Synonyms: ZRF, MTF-1, Metal regulatory transcription factor 1, MRE-binding transcription factor, Transcription factor MTF-1, MTF1
Target Information: This gene encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element (MRE). [provided by RefSeq, Jul 2008]