Description
Product Characteristics:
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Kr_ppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. Zinc finger and BTB domain-containing protein 48 (ZBTB48), also known as Kruppel-related zinc finger protein 3 or HKR3, is a 688 amino acid member of the Kr_ppel C2H2-type zinc-finger protein family. Localized to the nucleus, ZBTB48 is expressed in the adrenal gland and neuroblastoma cell lines. ZBTB48 contains a BTB domain, also known as a POZ domain, which inhibits DNA binding and mediates homotypic and heterotypic dimerization. Characteristics of the BTB domain suggest that ZBTB48 functions as a transcription regulator.
Subcellular location: Nucleus
Synonyms: 0610011D15Rik, AI327031, GLI Kruppel family member HKR3, HKR3, Krueppel related zinc finger protein 3, Krueppel-related zinc finger protein 3, OTTMUSP00000031803, pp9964, Protein HKR3, RP23-445E20.3, ZBT48_HUMAN, ZBTB 48, Zbtb48, Zinc finger and BTB domain containing 48, Zinc finger and BTB domain containing protein 48, Zinc finger and BTB domain-containing protein 48, Zinc finger protein 855, ZNF855.
Target Information: Binds to and regulates the J and/or S elements in MHC II promoter