Description
Product Characteristics:
Ficolin B is the designation in mouse and rat of a protein also known as L-ficolin, ficolin-2, collagen/fibrinogen domain-containing protein 2, serum lectin p35, EBP-37 or hucolin. Ficolin B is a 313 amino acid member of the ficolin lectin family. It is a secreted innate immunity pattern recognition molecule expressed in liver and plasma that forms a disulfide-linked homopolymer. This extensive N-terminal disulfide bridge formation can lead to a functional dodecamer polypeptide. Ficolin B binds to DNA ligands expressed by late apoptotic and necrotic cells to increase attachment and engulfment. Variation in ficolin B concentrations amongst individuals is associated with polymorphisms in the promoter and structural portion of the FCN2 gene. In patients with Beht's disease (BD), there exists a significant difference in allele frequency for FCN2 gene single nucleotide polymorphisms (SNPs) within the -557 and -64 promoter sites within HLA-B51 positive and HLA-B51 negative subgroups.
Subcellular location: Secreted
Synonyms: 37 kDa elastin-binding protein, Collagen/fibrinogen domain containing protein 2, Collagen/fibrinogen domain-containing protein 2, EBP 37, EBP-37, EBP37, FCN 2, Fcn2, FCN2_HUMAN, FCNL, Ficolin collagen/fibrinogen domain containing lectin 2 hucolin, Ficolin B, Ficolin beta, Ficolin-2, Ficolin-B, Ficolin-beta, Ficolin2, Hucolin, L ficolin, L-ficolin, OTTHUMP00000022518, P35, RP11 263F14.2, Serum lectin p35.
Target Information: The product of this gene belongs to the ficolin family of proteins. This family is characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. This gene is predominantly expressed in the liver, and has been shown to have carbohydrate binding and opsonic activities. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]