Description
Product Characteristics:
PIST (PDZ protein interacting specifically with TC10), also known as GOPC (golgi associated PDZ and coiled-coil motif containing), CAL or FIG, is a 462 amino acid protein that localizes to the cytoplasm, as well as to the membrane of the golgi apparatus and to the cell junction. Expressed ubiquitously and containing one PDZ (DHR) domain, PIST functions as a homooligomer that interacts with a variety of proteins and plays a role in intracellular protein trafficking and degradation. Additionally, PIST is thought to regulate ionic currents via membrane channel modification and may also play a role in autophagy. Chromosomal aberrations in the gene encoding PIST are found in glioblastoma multiform (GBM), a common and aggressive form of brain tumor, suggesting a role for mutated PIST in carcinogenesis. Three isoforms of PIST exist due to alternative splicing events.
Subcellular location: Cytoplasm, Cell membrane
Synonyms: CAL, CFTR associated ligand, CFTR-associated ligand, FIG, Fused in glioblastoma, Golgi associated PDZ and coiled coil mot containing, Golgi associated PDZ and coiled coil mot containing protein, Golgi-associated PDZ and coiled-coil mot-containing protein, GOPC, GOPC_HUMAN, GOPC1, OTTHUMP00000040403, PDZ protein interacting specically with TC 10, PDZ protein interacting specically with TC10, PDZ/coiled coil domain binding partner for the rho family GTPase TC 10, PDZ/coiled coil domain binding partner for the rho family GTPase TC10, PIST, Protein interacting specically with Tc 10, Protein interacting specically with Tc10, dJ94G16.2, dJ94G16.2 PIST.
Target Information: This gene encodes a Golgi protein with a PDZ domain. The PDZ domain is globular and proteins which contain them bind other proteins through short motifs near the C-termini. Mice which are deficient in the orthologous protein have globozoospermia and are infertile. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]