Description
Product Characteristics:
Emp is a 396 amino acid ubiquitously expressed adhesion protein. Expressed as 5 alternatively spliced isoforms, Emp contains one CTLH domain and one LisH domain. Emp can form a complex with F-actin, which is involved regulating actin distribution in erythroblasts and macrophages. Considered to assist with cell division and nuclear architecture, Emp is localized with condensed chromatin at prophase, nuclear spindle poles at metaphase and in the contractile ring during telophase and cytokinesis. Although the exact function of Emp is unknown, Emp is suggested to be involvement in erythroblast-macrophage cell attachment, terminal maturation and enucleation of erythroid cells, and inhibiting apoptosis of erythroblasts.
Subcellular location: Cytoplasm, Nucleus, Cell membrane
Synonyms: 1110030D19Rik, Cell proliferation inducing gene 5 protein, Cell proliferation-inducing gene 5 protein, EMP, Erythroblast macrophage protein, HLC 10, HLC-10, HLC10, Human lung cancer oncogene 10 protein, Lung cancer related protein 10, lung cancer-related protein 10, Macrophage erythroblast attacher, MAEA, MAEA_HUMAN, MGC93683, PIG5, proliferation-inducing gene 5.
Target Information: This gene product mediates the attachment of erythroblasts to macrophages. This attachment promotes terminal maturation and enucleation of erythroblasts, presumably by suppressing apoptosis. This protein is an integral membrane protein with the N-terminus on the extracellular side and the C-terminus on the cytoplasmic side of the cell. Two immunologically related isoforms of erythroblast macrophage protein with apparent molecular weights of 33 kD and 36 kD were detected in macrophage membranes\, this gene encodes the larger isoform. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]