Description
Product Characteristics:
IBP160
Subcellular location: Nucleus
Synonyms: AQR, AQR_HUMAN, aquarius, aquarius homolog (mouse), DKFZp686B23123, fSAP164, functional spliceosome-associated protein 164, IBP160, Intron-binding protein aquarius, Intron-binding protein of 160 kDa, KIAA0560.
Target Information: Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing