Description
Product Characteristics: Function: Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis. SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane, Single-pass membrane protein. Cell membrane, Single-pass membrane protein Tissue specificity: Expressed in the pyramidal cells of the prefrontal cortex, in hippothalamus and in caudate nucleus. No expression in spleen. Up-regulated in the prefrontal cortex of schizophrenic patients with nearly twice the levels of non-schizophrenics.,Neurodegeneration,CALY, Calcyon, Drd1ip
Target Information: The protein encoded by this gene is a type II single transmembrane protein. It is required for maximal stimulated calcium release after stimulation of purinergic or muscarinic but not beta-adrenergic receptors. The encoded protein interacts with D1 dopamine receptor and may interact with other DA receptor subtypes and/or GPCRs. [provided by RefSeq, Jul 2008]