Description
Product Characteristics:
Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. The protein is involved in regulation of ionic conductances and long term synaptic plasticity. It may play an important role in dephosphorylating substrates such as the postsynaptic density associated Ca (2+)/calmodulin dependent protein kinase II.PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC (PP1C gamma), which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting or regulatory subunits. PPP1R12A and PPP1R12B mediate binding to myosin. PPP1R3A, PPP1R3B, PPP1R3C and PPP1R3D mediate binding to glycogen.
Subcellular location: Cytoplasm, Nucleus
Synonyms: EC 3.1.3.16, PP 1G, PP-1G, PP1C gamma, PP1G, PP1G_HUMAN, PP1gamma, PPP 1G, PPP1CC, PPP1CC protein, PPP1G, Protein phosphatase 1 catalytic subunit gamma isoform, Protein Phosphatase 1 gamma 1, Protein Phosphatase 1 gamma, Protein phosphatase 1C catalytic subunit, Protein phosphatase 1C subunit, Protein phosphatase 2C gamma isoform, Serine/threonine phosphatase 1 gamma, Serine/threonine protein phosphatase PP1 gamma catalytic subunit, Serine/threonine-protein phosphatase PP1-gamma catalytic subunit.
Target Information: The protein encoded by this gene belongs to the protein phosphatase family, PP1 subfamily. PP1 is an ubiquitous serine/threonine phosphatase that regulates many cellular processes, including cell division. It is expressed in mammalian cells as three closely related isoforms, alpha, beta/delta and gamma, which have distinct localization patterns. This gene encodes the gamma isozyme. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]