Description
Product Characteristics: Function: Transcriptional activator. Binds in vitro to the CACCC motif of the beta-globin promoter and to the SP1 recognition sequence. Subcellular location: Nucleus Tissue specificity: Ubiquitous and highly expressed in brain and spinal cord in the adult, and in kidney and brain in the embryo.,Nuclear Signaling,Krueppel-like factor 7, Ubiquitous krueppel-like factor, UKLF
Target Information: The protein encoded by this gene is a member of the Kruppel-like transcriptional regulator family. Members in this family regulate cell proliferation, differentiation and survival and contain three C2H2 zinc fingers at the C-terminus that mediate binding to GC-rich sites. This protein may contribute to the progression of type 2 diabetes by inhibiting insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes. A pseudogene of this gene is located on the long arm of chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]