Description
Product Characteristics: SRCAP, Snf2-related CREBBP activator protein, DOMO1, EAF1, FLJ44499, KIAA0309, SWR1, OTTHUMP00000208671, Snf2-related CBP activator protein, Swi2/Snf2-related ATPase homolog, domino homolog 1, domino homolog 1, domino homolog 2, helicase SRCAP
Target Information: This gene encodes the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex. The encoded protein is an ATPase that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. It can function as a transcriptional activator in Notch-mediated, CREB-mediated and steroid receptor-mediated transcription. Mutations in this gene cause Floating-Harbor syndrome, a rare disorder characterized by short stature, language deficits and dysmorphic facial features. [provided by RefSeq, Feb 2012]