MyBioSource.com's MSLN (Mesothelin, CAK1 Antigen, MPF, Pre-pro-megakaryocyte-potentiating Factor, SMR) is a Human, and Mouse monoclonal antibody. The MSLN (Mesothelin, CAK1 Antigen, MPF, Pre-pro-megakaryocyte-potentiating Factor, SMR) Antibody was generated using Mesothelin, MPF, and Msln as the antigen. It reacts with Human. This antibody has been shown to work in applications such as: ELISA, and Western Blot.
Description
Megakaryocyte Potentiating Factor (MPF) is a 33kD soluble protein that is cleaved as an N-terminal propeptide from the mouse mesothelin preproprotein by furin, while the C-terminal portion is processed further to form mesothelin. Mouse MPF potentiates megakaryocyte colony forming activity of IL-3 in mouse bone marrow culture. Human MPF shows 55% aa identity with mouse or rat MPF. The preproprotein is produced by mesothelial cells and is also highly expressed in pancreatic, gastric and ovarian carcinomas