Description
Product Characteristics: FUNCTION: High affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. SUBCELLULAR LOCATION: Cell membrane, Multi-pass membrane protein TISSUE SPECIFICITY: Neutrophils,Innate Immunity,fMet-Leu-Phe receptor, fMLP receptor, N-formyl peptide receptor, FPR, N formylpeptide chemoattractant receptor
Target Information: This gene encodes a G protein-coupled receptor of mammalian phagocytic cells that is a member of the G-protein coupled receptor 1 family. The protein mediates the response of phagocytic cells to invasion of the host by microorganisms and is important in host defense and inflammation.[provided by RefSeq, Jul 2010]