Description
Product Characteristics: FUNCTION: Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Mitochondrion. Early endosome. Endosome. Note: Predominantly associated with early endosome. The localization to early endosomes depends on its interaction with HRS. TISSUE SPECIFICITY: High expression in spinal cord and moderate expression in all other tissues and specific brain regions examined. Expressed in all cell lines examined. Over-expressed in all investigated carcinomas, especially in gastric adenocarcinoma and signet-ring carcinoma and may serve as a marker of gastric cancer.,Vesicle Transport,Trafficking kinesin-binding protein 1, 106 kDa O-GlcNAc transferase-interacting protein
Target Information: Involved in the regulation of endosome-to-lysosome trafficking, including endocytic of EGF-EGFR complexes and GABA-A receptors (By similarity)