Description
Product Characteristics:
Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.
Subcellular location: Cytoplasm
Synonyms: CDD, VBCH, SOST1, Sclerostin, SOST, UNQ2976/PRO7455/PRO7476
Target Information: Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease. [provided by RefSeq, Jul 2008]