Description
Product Characteristics:
Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.
Subcellular location: Cell membrane
Synonyms: GAT3, GAT4, GAT-3, Sodium- and chloride-dependent GABA transporter 3, Solute carrier family 6 member 11, SLC6A11, GABT3
Target Information: Gamma-aminobutyric acid (GABA) is a major inhibitory neurotransmitter. GABAergic neurotransmission is terminated by the uptake of GABA into the presynaptic terminal and the surrounding astroglial cells by sodium-dependent transporters, such as SLC6A11 (Borden et al., 1994 [PubMed 7874447]).[supplied by OMIM, Nov 2010]