Description
Product Characteristics: Histone H2B is a core component of nucleosome that facilitates nucleosome wrapping and DNA compacting into chromatin. This limits the accessibility of DNA to the cellular machineries for which DNA is required as a template. Histones thereby play a central role in transcription regulation, DNA repair and replication as well as chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, of which the process is called the histone code, and nucleosome remodeling.Rabbit Anti-Histone H2B (Acetyl-K20) Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic acetylpeptide corresponding to residues surrounding Lys20 of human Histone H2B. (Swiss Prot: Q5QNW6).
Target Information: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Jul 2008]