Description
Product Characteristics:
Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Required for normal iron homeostasis. Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1.
Subcellular location: Cytoplasm
Synonyms: C14orf87, Chromosome 14 open reading frame 87, FLB4739, GLRX 5, Glrx5, GLRX5_HUMAN, Glutaredoxin 5 homolog, Glutaredoxin related protein 5, Glutaredoxin-related protein 5, Glutaredoxin5, GRX5, MGC14129, mitochondrial, Monothiol glutaredoxin-5, PRO1238.
Target Information: This gene encodes a mitochondrial protein, which is evolutionarily conserved. It is involved in the biogenesis of iron-sulfur clusters, which are required for normal iron homeostasis. Mutations in this gene are associated with autosomal recessive pyridoxine-refractory sideroblastic anemia. [provided by RefSeq, May 2010]